Development of Gastric Carcinoma from Intestinal Metaplasia in Cdx2-transgenic Mice
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- Hiroyuki Mutoh
- 1Gastroenterology and Departments of
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- Shinji Sakurai
- 2Pathology, Jichi Medical School, Tochigi, Japan
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- Kiichi Satoh
- 1Gastroenterology and Departments of
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- Kiichi Tamada
- 1Gastroenterology and Departments of
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- Hiroto Kita
- 1Gastroenterology and Departments of
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- Hiroyuki Osawa
- 1Gastroenterology and Departments of
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- Takeshi Tomiyama
- 1Gastroenterology and Departments of
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- Yukihiro Sato
- 1Gastroenterology and Departments of
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- Hironori Yamamoto
- 1Gastroenterology and Departments of
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- Norio Isoda
- 1Gastroenterology and Departments of
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- Toru Yoshida
- 1Gastroenterology and Departments of
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- Kenichi Ido
- 1Gastroenterology and Departments of
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- Kentaro Sugano
- 1Gastroenterology and Departments of
書誌事項
- 公開日
- 2004-11-01
- DOI
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- 10.1158/0008-5472.can-04-1617
- 公開者
- American Association for Cancer Research (AACR)
この論文をさがす
説明
<jats:title>Abstract</jats:title> <jats:p>In the progression of chronic gastritis, gastric mucosal cells deviate from the normal pathway of gastric differentiation to an intestinal phenotype. Many epidemiologic studies have found an association between the formation of intestinal metaplasia and the development of gastric carcinoma. However, there is no direct evidence that shows intestinal metaplasia is a precursor lesion of gastric carcinoma, to date. We periodically examined the intestinal metaplastic mucosa of Cdx2-transgenic mice we have previously generated. Gastric polyps developed from intestinal metaplastic mucosa in all stomachs of Cdx2-transgenic mice examined. These gastric polyps consisted of intestinal-type adenocarcinoma that invaded the submucosa and muscularis propria and occasionally spread into the subserosa. p53 and APC gene mutations were recognized in the adenocarcinomas. The participation of APC and p53 gene mutations in gastric carcinogenesis from the intestinal metaplasia was verified by the Cdx2-transgenic mice, carrying ApcMin mutation or p53 deficiency, that developed gastric polyps much earlier than Cdx2 alone. We successfully showed that long-term intestinal metaplasia induces invasive gastric carcinoma. These results indicate that intestinal metaplasia itself plays a significant role in the genesis and progression of gastric carcinoma.</jats:p>
収録刊行物
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- Cancer Research
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Cancer Research 64 (21), 7740-7747, 2004-11-01
American Association for Cancer Research (AACR)
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詳細情報 詳細情報について
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- CRID
- 1362262943600433792
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- NII論文ID
- 30018590694
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- ISSN
- 15387445
- 00085472
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- データソース種別
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