Aquaporin 4: A key player in Parkinson's disease

DOI Web Site Web Site 1 Citations
  • Omid Reza Tamtaji
    Research Center for Biochemistry and Nutrition in Metabolic Diseases Kashan University of Medical Sciences Kashan Iran
  • Mohammad Behnam
    Halal Research Center of IRI, FDA Tehran Iran
  • Mohammad Ali Pourattar
    Department of Radiobiology Iran University of Medical Sciences Tehran Iran
  • Hamed Jafarpour
    Student Research Committee Mazandaran University of Medical Science Sari Iran
  • Zatollah Asemi
    Research Center for Biochemistry and Nutrition in Metabolic Diseases Kashan University of Medical Sciences Kashan Iran

Description

<jats:title>Abstract</jats:title><jats:p>Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases which occur in aged people worldwide. Given that a sequence of cellular and molecular mechanisms, including oxidative stresses, apoptosis, inflammatory pathways, microglia, astrocyte activation, and aquaporin 4 (AQP4) are associated with initiation and the progression of PD. AQP4 may affect various pathways (i.e., α‐synuclein, inflammatory pathways, and microglia and astrocyte activation). Few reports have evaluated the relationship between AQP4 and PD‐related cellular and molecular pathways. Here, for the first time, we highlighted the relationship between AQP4 and molecular mechanisms involved in PD pathogenesis.</jats:p>

Journal

Citations (1)*help

See more

Report a problem

Back to top