Changes in intramuscular collagen and fibronectin in denervation atrophy

Vesa Salonen, Matti Lehto, Hannu Kalimo, Risto Penttinen, Hannu Aro

doi:10.1002/mus.880080208

Changes in intramuscular collagen and fibronectin in denervation atrophy

DOI Web Site Web Site 被引用文献2件

書誌事項

公開日: 1985-02

権利情報

http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1002/mus.880080208

公開者: Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>The distribution of collagen types I, III, and V and fibronectin was investigated by means of immunofluorescent techniques in denervated and normal rat skeletal muscle. During a period of 28 days, a distinct atrophy developed in the denervated gastrocnemius muscle and was accompanied by an increase in types I and III collagen in the endomysium and perimysium. The amount of type V collagen showed little change, whereas fibronectin increase closely parallelled types I and III collagen. The results indicate that denervation atrophy in muscles is accompanied by striking fibrotic changes due to mesenchymal types I and III collagen.</jats:p>