Sesamin is a potent and specific inhibitor of Δ5 desaturase in polyunsaturated fatty acid biosynthesis
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- Sakayu Shimizu
- Department of Agricultural Chemistry Kyoto University Sakyo‐ku Kyoto 606
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- Kengo Akimoto
- Department of Agricultural Chemistry Kyoto University Sakyo‐ku Kyoto 606
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- Yoshifumi Shinmen
- Department of Agricultural Chemistry Kyoto University Sakyo‐ku Kyoto 606
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- Hiroshi Kawashima
- Department of Agricultural Chemistry Kyoto University Sakyo‐ku Kyoto 606
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- Michihiro Sugano
- Department of Food Science and Technology Kyushu University Higashi‐ku Fukuoka 812 Japan
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- Hideaki Yamada
- Department of Agricultural Chemistry Kyoto University Sakyo‐ku Kyoto 606
書誌事項
- 公開日
- 1991-07
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1007/bf02536595
- 公開者
- Wiley
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説明
<jats:title>Abstract</jats:title><jats:p>Incubation with sesame oil increases the mycelial dihomo‐γ‐linolenic acid content of an arachidonic acid‐producing fungus,<jats:italic>Mortierella alpina</jats:italic>, but decreases its arachidonic acid content [Shimizu, S., K. Akimoto, H. Kawashima, Y. Shinmen and H. Yamada (1989)<jats:italic>J. Am. Oil Chem. Soc. 66</jats:italic>, 237–241]. The factor causing these effects was isolated and identified to be (+)‐sesamin. The results obtained in experiments with both a cell‐free extract of the fungus and with rat liver microsomes demonstrated that (+)‐sesamin specifically inhibits Δ5 desaturase at low concentrations, but does not inhibit Δ6, Δ9 and Δ12 desaturases. Kinetic analysis showed that (+)‐sesamin is a noncompetitive inhibitor (K<jats:sub>i</jats:sub> for rat liver Δ5 desaturase, 155 μM). (+)‐Sesamolin, (+)‐sesaminol and (+)‐episesamin, also inhibited only Δ5 desaturases of the fungus and liver. These results demonstrate that (+)‐sesamin and related lignan compounds present in sesame seeds or its oil are specific inhibitors of Δ5 desaturase in polyunsaturated fatty acid biosynthesis in both microorganisms and animals.</jats:p>
収録刊行物
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- Lipids
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Lipids 26 (7), 512-516, 1991-07
Wiley
