Sedlin Controls the ER Export of Procollagen by Regulating the Sar1 Cycle

DOI Web Site 19 Citations
  • Rossella Venditti
    Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, Naples 80131, Italy.
  • Tiziana Scanu
    Consorzio Mario Negri Sud, Via Nazionale, Santa Maria Imbaro (Chieti) 66030, Italy.
  • Michele Santoro
    Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, Naples 80131, Italy.
  • Giuseppe Di Tullio
    Consorzio Mario Negri Sud, Via Nazionale, Santa Maria Imbaro (Chieti) 66030, Italy.
  • Alexander Spaar
    Consorzio Mario Negri Sud, Via Nazionale, Santa Maria Imbaro (Chieti) 66030, Italy.
  • Renato Gaibisso
    Consorzio Mario Negri Sud, Via Nazionale, Santa Maria Imbaro (Chieti) 66030, Italy.
  • Galina V. Beznoussenko
    Consorzio Mario Negri Sud, Via Nazionale, Santa Maria Imbaro (Chieti) 66030, Italy.
  • Alexander A. Mironov
    Consorzio Mario Negri Sud, Via Nazionale, Santa Maria Imbaro (Chieti) 66030, Italy.
  • Alexander Mironov
    Consorzio Mario Negri Sud, Via Nazionale, Santa Maria Imbaro (Chieti) 66030, Italy.
  • Leopoldo Zelante
    Medical Genetics Unit, IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Foggia, Italy.
  • Maria Rosaria Piemontese
    Medical Genetics Unit, IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Foggia, Italy.
  • Angelo Notarangelo
    Medical Genetics Unit, IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Foggia, Italy.
  • Vivek Malhotra
    Department of Cell and Developmental Biology, Centre de Regulacio Genomica, 08010 Barcelona, Spain.
  • Barbara M. Vertel
    Department of Cell Biology and Anatomy, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.
  • Cathal Wilson
    Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, Naples 80131, Italy.
  • Maria Antonietta De Matteis
    Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, Naples 80131, Italy.

Description

<jats:title>A Tight Squeeze</jats:title> <jats:p> During intracellular transport, the export of procollagen from the endoplasmic reticulum is intriguing because procollagen is too large to fit into conventional coat protein complex II (COPII)–coated transport vesicles. Recent work has implicated the receptor TANGO1 in procollagen export. Now, <jats:bold> Venditti <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="1668" related-article-type="in-this-issue" vol="337" xlink:href="10.1126/science.1224947">1668</jats:related-article> ) report that TANGO1 recruits Sedlin—also known as TRAPPC2, a homolog of the yeast TRAPP subunit Trs20—and helps to allow COPII-coated carriers to grow large enough to incorporate procollagen. </jats:p>

Journal

  • Science

    Science 337 (6102), 1668-1672, 2012-09-28

    American Association for the Advancement of Science (AAAS)

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