Arabidopsis FORGETTER1 mediates stress-induced chromatin memory through nucleosome remodeling
-
- Krzysztof Brzezinka
- Institute for Biochemistry and Biology, University of Potsdam, Potsdam, Germany
-
- Simone Altmann
- Institute for Biochemistry and Biology, University of Potsdam, Potsdam, Germany
-
- Hjördis Czesnick
- Institute for Biochemistry and Biology, University of Potsdam, Potsdam, Germany
-
- Philippe Nicolas
- Institute for Biochemistry and Biology, University of Potsdam, Potsdam, Germany
-
- Michal Gorka
- Max-Planck-Institute for Molecular Plant Physiology, Potsdam, Germany
-
- Eileen Benke
- Institute for Biochemistry and Biology, University of Potsdam, Potsdam, Germany
-
- Tina Kabelitz
- Institute for Biochemistry and Biology, University of Potsdam, Potsdam, Germany
-
- Felix Jähne
- Institute for Biochemistry and Biology, University of Potsdam, Potsdam, Germany
-
- Alexander Graf
- Max-Planck-Institute for Molecular Plant Physiology, Potsdam, Germany
-
- Christian Kappel
- Institute for Biochemistry and Biology, University of Potsdam, Potsdam, Germany
-
- Isabel Bäurle
- Institute for Biochemistry and Biology, University of Potsdam, Potsdam, Germany
説明
<jats:p>Plants as sessile organisms can adapt to environmental stress to mitigate its adverse effects. As part of such adaptation they maintain an active memory of heat stress for several days that promotes a more efficient response to recurring stress. We show that this heat stress memory requires the activity of the FORGETTER1 (FGT1) locus, with fgt1 mutants displaying reduced maintenance of heat-induced gene expression. FGT1 encodes the Arabidopsis thaliana orthologue of Strawberry notch (Sno), and the protein globally associates with the promoter regions of actively expressed genes in a heat-dependent fashion. FGT1 interacts with chromatin remodelers of the SWI/SNF and ISWI families, which also display reduced heat stress memory. Genomic targets of the BRM remodeler overlap significantly with FGT1 targets. Accordingly, nucleosome dynamics at loci with altered maintenance of heat-induced expression are affected in fgt1. Together, our results suggest that by modulating nucleosome occupancy, FGT1 mediates stress-induced chromatin memory.</jats:p>
収録刊行物
-
- eLife
-
eLife 5 e17061-, 2016-09-28
eLife Sciences Publications, Ltd