Enantioselective Synthesis of Axially Chiral 1‐Arylisoquinolines by Rhodium‐Catalyzed [2+2+2] Cycloaddition
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説明
The enantioselective synthesis of axially chiral 1-arylisoquinolines by rhodium-catalyzed [2+2+2]-cycloaddn. of 1,6-diynes and isoquinolinyl alkynes has been developed. The diphenylphosphinoyl-substituted axially chiral 1-arylisoquinolines, e.g., I, were successfully derivatized to the corresponding axially chiral P,N ligand and Lewis base catalyst. [on SciFinder(R)] ; The enantioselective synthesis of axially chiral 1-arylisoquinolines by rhodium-catalyzed [2+2+2]-cycloaddn. of 1,6-diynes and isoquinolinyl alkynes has been developed. The diphenylphosphinoyl-substituted axially chiral 1-arylisoquinolines, e.g., I, were successfully derivatized to the corresponding axially chiral P,N ligand and Lewis base catalyst. [on SciFinder(R)]
収録刊行物
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- Chemistry – A European Journal
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Chemistry – A European Journal 17 (5), 1428-1432, 2011-01-05
Wiley