Endothelial cell motility, coordination and pattern formation during vasculogenesis
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- Andras Czirok
- Department of Anatomy and Cell Biology University of Kansas Medical Center Kansas City KS USA
書誌事項
- 公開日
- 2013-07-15
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/wsbm.1233
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>How vascular networks assemble is a fundamental problem of developmental biology that also has medical importance. To explain the organizational principles behind vascular patterning, we must understand how can tissue level structures be controlled through cell behavior patterns like motility and adhesion that, in turn, are determined by biochemical signal transduction processes? We discuss the various ideas that have been proposed as mechanisms for vascular network assembly: cell motility guided by extracellular matrix alignment (contact guidance), chemotaxis guided by paracrine and autocrine morphogens, and multicellular sprouting guided by cell–cell contacts. All of these processes yield emergent patterns, thus endothelial cells can form an interconnected structure autonomously, without guidance from an external pre‐pattern. <jats:italic>WIREs Syst Biol Med</jats:italic> 2013, 5:587–602. doi: 10.1002/wsbm.1233</jats:p><jats:p>This article is categorized under: <jats:list list-type="explicit-label"> <jats:list-item><jats:p>Models of Systems Properties and Processes > Cellular Models</jats:p></jats:list-item> <jats:list-item><jats:p>Developmental Biology > Developmental Processes in Health and Disease</jats:p></jats:list-item> <jats:list-item><jats:p>Models of Systems Properties and Processes > Organ, Tissue, and Physiological Models</jats:p></jats:list-item> </jats:list></jats:p>
収録刊行物
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- WIREs Systems Biology and Medicine
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WIREs Systems Biology and Medicine 5 (5), 587-602, 2013-07-15
Wiley
