Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease
書誌事項
- 公開日
- 2008-04-15
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/ana.21405
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for <jats:italic>leucine‐rich repeat kinase 2 (LRRK2)</jats:italic> c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20–2.83; <jats:italic>p</jats:italic> = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of <jats:italic>LRRK2</jats:italic> variants in sporadic Parkinson's disease. Ann Neurol 2008</jats:p>
収録刊行物
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- Annals of Neurology
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Annals of Neurology 64 (1), 88-92, 2008-04-15
Wiley
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キーワード
- Genetic Markers
- Male
- Singapore
- Polymorphism, Genetic
- Genotype
- DNA Mutational Analysis
- Taiwan
- Parkinson Disease
- Middle Aged
- Protein Serine-Threonine Kinases
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Founder Effect
- Asian People
- Gene Frequency
- Mutation
- Humans
- Female
- Genetic Predisposition to Disease
- Genetic Testing
詳細情報 詳細情報について
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- CRID
- 1362262943786043264
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- ISSN
- 15318249
- 03645134
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- PubMed
- 18688798
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- データソース種別
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- Crossref
- OpenAIRE