NMDA Receptor-Dependent Synaptic Reinforcement as a Crucial Process for Memory Consolidation

DOI Web Site 被引用文献19件
  • Eiji Shimizu
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544–1014, USA.
  • Ya-Ping Tang
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544–1014, USA.
  • Claire Rampon
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544–1014, USA.
  • Joe Z. Tsien
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544–1014, USA.

書誌事項

公開日
2000-11-10
DOI
  • 10.1126/science.290.5494.1170
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p> The hippocampal CA1 region is crucial for converting new memories into long-term memories, a process believed to continue for week(s) after initial learning. By developing an inducible, reversible, and CA1-specific knockout technique, we could switch <jats:italic>N</jats:italic> -methyl- <jats:sc>d</jats:sc> -aspartate (NMDA) receptor function off or on in CA1 during the consolidation period. Our data indicate that memory consolidation depends on the reactivation of the NMDA receptor, possibly to reinforce site-specific synaptic modifications to consolidate memory traces. Such a synaptic reinforcement process may also serve as a cellular means by which the new memory is transferred from the hippocampus to the cortex for permanent storage. </jats:p>

収録刊行物

  • Science

    Science 290 (5494), 1170-1174, 2000-11-10

    American Association for the Advancement of Science (AAAS)

被引用文献 (19)*注記

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