The topography of brain damage at different stages of Parkinson's disease

DOI Web Site Web Site 被引用文献3件
  • Federica Agosta
    Neuroimaging Research Unit Institute of Experimental Neurology Division of Neuroscience San Raffaele Scientific Institute Vita‐Salute San Raffaele University Milan Italy
  • Elisa Canu
    Neuroimaging Research Unit Institute of Experimental Neurology Division of Neuroscience San Raffaele Scientific Institute Vita‐Salute San Raffaele University Milan Italy
  • Tanja Stojković
    Clinic of Neurology Faculty of Medicine University of Belgrade Belgrade Serbia
  • Michela Pievani
    Neuroimaging Research Unit Institute of Experimental Neurology Division of Neuroscience San Raffaele Scientific Institute Vita‐Salute San Raffaele University Milan Italy
  • Aleksandra Tomić
    Clinic of Neurology Faculty of Medicine University of Belgrade Belgrade Serbia
  • Lidia Sarro
    Neuroimaging Research Unit Institute of Experimental Neurology Division of Neuroscience San Raffaele Scientific Institute Vita‐Salute San Raffaele University Milan Italy
  • Nataša Dragašević
    Clinic of Neurology Faculty of Medicine University of Belgrade Belgrade Serbia
  • Massimiliano Copetti
    Biostatistics Unit IRCCS‐Ospedale Casa Sollievo della Sofferenza San Giovanni Rotondo, Foggia Italy
  • Giancarlo Comi
    Department of Neurology Institute of Experimental Neurology Division of Neuroscience San Raffaele Scientific Institute Vita‐Salute San Raffaele University Milan Italy
  • Vladimir S. Kostić
    Clinic of Neurology Faculty of Medicine University of Belgrade Belgrade Serbia
  • Massimo Filippi
    Neuroimaging Research Unit Institute of Experimental Neurology Division of Neuroscience San Raffaele Scientific Institute Vita‐Salute San Raffaele University Milan Italy

書誌事項

公開日
2012-04-24
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1002/hbm.22101
公開者
Wiley

この論文をさがす

説明

<jats:p>This study investigated gray matter (GM) and white matter (WM) damage in 89 patients at different clinical stages of Parkinson's disease (PD) (17 early, 46 mild, 14 moderate, and 12 severe) to differentiate the trajectories of tissue injury in this condition. PD patients had a very little GM atrophy even at the more advanced stages of the disease. Microstructural damage to the WM occurs with increasing PD severity and involves the brainstem, thalamocortical pathways, olfactory tracts, as well as the major interhemispheric, limbic, and extramotor association tracts. The most marked WM damage was found in moderate vs. mild cases. WM damage correlated with the degree of global cognitive deficits. WM abnormalities beyond the nigrostriatal system accumulate with increasing PD severity. WM damage is likely to contribute to the more severe motor and nonmotor dysfunctions occurring in patients at the later stages. Hum Brain Mapp 34:2798–2807, 2013. © 2012 Wiley Periodicals, Inc.</jats:p>

収録刊行物

被引用文献 (3)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ