Prefrontal inputs to the amygdala instruct fear extinction memory formation

  • Olena Bukalo
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20853, USA.
  • Courtney R. Pinard
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20853, USA.
  • Shana Silverstein
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20853, USA.
  • Christina Brehm
    Department of Pharmacology and Toxicology, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80-82/III, A-6020 Innsbruck, Austria.
  • Nolan D. Hartley
    Department of Psychiatry and Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Nigel Whittle
    Department of Pharmacology and Toxicology, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80-82/III, A-6020 Innsbruck, Austria.
  • Giovanni Colacicco
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20853, USA.
  • Erica Busch
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20853, USA.
  • Sachin Patel
    Department of Psychiatry and Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Nicolas Singewald
    Department of Pharmacology and Toxicology, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80-82/III, A-6020 Innsbruck, Austria.
  • Andrew Holmes
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20853, USA.

Description

<jats:p>Traumatic fear memories are extinguished by a discrete brain circuit comprising inputs from the prefrontal cortex to the amygdala.</jats:p>

Journal

  • Science Advances

    Science Advances 1 (6), e1500251-, 2015-07-03

    American Association for the Advancement of Science (AAAS)

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