In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse

DOI Web Site 被引用文献97件
  • Steven R. Schwarze
    Howard Hughes Medical Institute and Departments of Pathology and Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Alan Ho
    Howard Hughes Medical Institute and Departments of Pathology and Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Adamina Vocero-Akbani
    Howard Hughes Medical Institute and Departments of Pathology and Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Steven F. Dowdy
    Howard Hughes Medical Institute and Departments of Pathology and Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

書誌事項

公開日
1999-09-03
DOI
  • 10.1126/science.285.5433.1569
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p>Delivery of therapeutic proteins into tissues and across the blood-brain barrier is severely limited by the size and biochemical properties of the proteins. Here it is shown that intraperitoneal injection of the 120-kilodalton β-galactosidase protein, fused to the protein transduction domain from the human immunodeficiency virus TAT protein, results in delivery of the biologically active fusion protein to all tissues in mice, including the brain. These results open new possibilities for direct delivery of proteins into patients in the context of protein therapy, as well as for epigenetic experimentation with model organisms.</jats:p>

収録刊行物

  • Science

    Science 285 (5433), 1569-1572, 1999-09-03

    American Association for the Advancement of Science (AAAS)

被引用文献 (97)*注記

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