Plasmacytoid Dendritic Cell Dynamics and Alpha Interferon Production during Simian Immunodeficiency Virus Infection with a Nonpathogenic Outcome
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- Ousmane M. Diop
- Institut Pasteur, Dakar, Sénégal
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- Mickaël J.-Y. Ploquin
- Institut Pasteur, Unité de Régulation des Infections Rétrovirales, 75015 Paris, France
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- Lorenzo Mortara
- Institut Pasteur, Unité de Régulation des Infections Rétrovirales, 75015 Paris, France
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- Abdourahmane Faye
- Institut Pasteur, Dakar, Sénégal
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- Béatrice Jacquelin
- Institut Pasteur, Unité de Régulation des Infections Rétrovirales, 75015 Paris, France
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- Désirée Kunkel
- Institut Pasteur, Unité de Régulation des Infections Rétrovirales, 75015 Paris, France
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- Pierre Lebon
- Hôpital Saint-Vincent de Paul et Université Paris 5, Service de Virologie, 75014 Paris, France
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- Cécile Butor
- Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), 75014 Paris, France
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- Anne Hosmalin
- Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), 75014 Paris, France
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- Françoise Barré-Sinoussi
- Institut Pasteur, Unité de Régulation des Infections Rétrovirales, 75015 Paris, France
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- Michaela C. Müller-Trutwin
- Institut Pasteur, Unité de Régulation des Infections Rétrovirales, 75015 Paris, France
書誌事項
- 公開日
- 2008-06
- 権利情報
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- https://journals.asm.org/non-commercial-tdm-license
- DOI
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- 10.1128/jvi.02433-07
- 公開者
- American Society for Microbiology
この論文をさがす
説明
<jats:title>ABSTRACT</jats:title> <jats:p>We addressed the role of plasmacytoid dendritic cells (PDC) in protection against AIDS in nonpathogenic simian immunodeficiency virus (SIVagm) infection in African green monkeys (AGMs). PDC were monitored in blood and lymph nodes (LNs) starting from day 1 postinfection. We observed significant declines in blood during acute infection. However, PDC then returned to normal levels, and chronically infected AGMs showed no decrease of PDC in blood. There was a significant increase of PDC in LNs during acute infection. Blood PDC displayed only weak alpha interferon (IFN-α) responses to TLR9 agonist stimulation before infection. However, during acute infection, both blood and LN PDC showed a transiently increased propensity for IFN-α production. Bioactive IFN-α was detected in plasma concomitant with the peak of viremia, though levels were only low to moderate in some animals. Plasma interleukin 6 (IL-6) and IL-12 were not increased. In conclusion, PDC were recruited to the LNs and displayed increased IFN-α production during acute infection. However, increases in IFN-α were transient. Together with the lack of inflammatory cytokine responses, these events might play an important role in the low level of T-cell activation which is associated with protection against AIDS in nonpathogenic SIVagm infection.</jats:p>
収録刊行物
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- Journal of Virology
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Journal of Virology 82 (11), 5145-5152, 2008-06
American Society for Microbiology