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- Oskar Hallatschek
- *Department of Physics and
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- Pascal Hersen
- FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138;
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- Sharad Ramanathan
- FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138;
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- David R. Nelson
- *Department of Physics and
書誌事項
- 公開日
- 2007-12-11
- DOI
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- 10.1073/pnas.0710150104
- 公開者
- Proceedings of the National Academy of Sciences
この論文をさがす
説明
<jats:p> Competition between random genetic drift and natural selection play a central role in evolution: Whereas nonbeneficial mutations often prevail in small populations by chance, mutations that sweep through large populations typically confer a selective advantage. Here, however, we observe chance effects during range expansions that dramatically alter the gene pool even in large microbial populations. Initially well mixed populations of two fluorescently labeled strains of <jats:italic>Escherichia coli</jats:italic> develop well defined, sector-like regions with fractal boundaries in expanding colonies. The formation of these regions is driven by random fluctuations that originate in a thin band of pioneers at the expanding frontier. A comparison of bacterial and yeast colonies ( <jats:italic>Saccharomyces cerevisiae</jats:italic> ) suggests that this large-scale genetic sectoring is a generic phenomenon that may provide a detectable footprint of past range expansions. </jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 104 (50), 19926-19930, 2007-12-11
Proceedings of the National Academy of Sciences