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- Allan A Kaspar
- Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University School of Medicine , Stanford, CA 94305
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- Satoshi Okada
- Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University School of Medicine , Stanford, CA 94305
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- Jayant Kumar
- Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University School of Medicine , Stanford, CA 94305
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- Francis R Poulain
- Department of Pediatrics, University of California , San Francisco, CA 94143
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- Katerina A Drouvalakis
- Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University School of Medicine , Stanford, CA 94305
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- Ameeta Kelekar
- Gwen Knapp Center for Lupus and Immunology Research, Howard Hughes Medical Institute, University of Chicago , Chicago, IL 60637
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- Dennis A Hanson
- Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University School of Medicine , Stanford, CA 94305
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- Ruth M Kluck
- Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology , San Diego, CA 92121
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- Yasumichi Hitoshi
- Department of Molecular Pharmacology, Stanford University School of Medicine , Stanford, CA 94305
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- Daniel E Johnson
- Department of Medicine, University of Pittsburgh , Pittsburgh, PA 15213
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- Christopher J Froelich
- Evanston Northwestern Research Institute, Northwestern University , Evanston, IL 60201
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- Craig B Thompson
- Abramson Family Cancer Research Institute, University of Pennsylvania , Philadelphia, PA 19104
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- Donald D Newmeyer
- Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology , San Diego, CA 92121
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- Alberto Anel
- Department of Bioquimica, Facultad de Ciencias, Universidad de Zaragoza , Zaragoza ,
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- Carol Clayberger
- Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University School of Medicine , Stanford, CA 94305
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- Alan M Krensky
- Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University School of Medicine , Stanford, CA 94305
書誌事項
- 公開日
- 2001-07-01
- 権利情報
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- https://academic.oup.com/pages/standard-publication-reuse-rights
- DOI
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- 10.4049/jimmunol.167.1.350
- 公開者
- Oxford University Press (OUP)
この論文をさがす
説明
<jats:title>Abstract</jats:title> <jats:p>Granulysin is an antimicrobial and tumoricidal molecule expressed in granules of CTL and NK cells. In this study, we show that granulysin damages cell membranes based upon negative charge, disrupts the transmembrane potential (Δψ) in mitochondria, and causes release of cytochrome c. Granulysin-induced apoptosis is blocked in cells overexpressing Bcl-2. Despite the release of cytochrome c, procaspase 9 is not processed. Nevertheless, activation of caspase 3 is observed in granulysin-treated cells, suggesting that granulysin activates a novel pathway of CTL- and NK cell-mediated death distinct from granzyme- and death receptor-induced apoptosis.</jats:p>
収録刊行物
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- The Journal of Immunology
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The Journal of Immunology 167 (1), 350-356, 2001-07-01
Oxford University Press (OUP)