Total Synthesis of (−)‐FR182877 through Tandem IMDA–IMHDA Reactions and Stereoselective Transition‐Metal‐Mediated Transformations
書誌事項
- 公開日
- 2009-03-17
- 権利情報
-
- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
-
- 10.1002/anie.200900097
- 10.1002/ange.200900097
- 10.1002/chin.200929206
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p><jats:bold>Intelligent design</jats:bold>: The total synthesis of the cytotoxic (−)‐FR182877 relies on 1) tandem Diels–Alder reactions to close rings A–D (see scheme), 2) a palladium‐mediated 7‐<jats:italic>exo</jats:italic>‐trig reaction, and 3) an iridium‐mediated isomerization followed by epimerization and stereoselective reduction.<jats:boxed-text content-type="graphic" position="anchor"><jats:graphic xmlns:xlink="http://www.w3.org/1999/xlink" mimetype="image/gif" position="anchor" specific-use="enlarged-web-image" xlink:href="graphic/mcontent.gif"><jats:alt-text>magnified image</jats:alt-text></jats:graphic></jats:boxed-text></jats:p>
収録刊行物
-
- Angewandte Chemie International Edition
-
Angewandte Chemie International Edition 48 (14), 2580-2583, 2009-03-17
Wiley