<i>Aggregatibacter actinomycetemcomitans</i> –induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis

DOI Web Site 10 Citations
  • Maximilian F. Konig
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
  • Loreto Abusleme
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
  • Jesper Reinholdt
    Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
  • Robert J. Palmer
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
  • Ricardo P. Teles
    Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Kevon Sampson
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
  • Antony Rosen
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
  • Peter A. Nigrovic
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA 02115, USA.
  • Jeremy Sokolove
    Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Jon T. Giles
    Division of Rheumatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
  • Niki M. Moutsopoulos
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
  • Felipe Andrade
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.

Abstract

<jats:p> <jats:italic>Aggregatibacter actinomycetemcomitans</jats:italic> generates citrullinated autoantigens involved in rheumatoid arthritis through its pore-forming toxin leukotoxin A. </jats:p>

Journal

  • Science Translational Medicine

    Science Translational Medicine 8 (369), 369ra176-, 2016-12-14

    American Association for the Advancement of Science (AAAS)

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