Discovery and Genomic Characterization of a 382-Nucleotide Deletion in ORF7b and ORF8 during the Early Evolution of SARS-CoV-2

DOI Web Site 被引用文献6件

書誌事項

公開日
2020-08-25
権利情報
  • https://creativecommons.org/licenses/by/4.0/
  • https://journals.asm.org/non-commercial-tdm-license
DOI
  • 10.1128/mbio.01610-20
公開者
American Society for Microbiology

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説明

<jats:p>During the SARS epidemic in 2003/2004, a number of deletions were observed in ORF8 of SARS-CoV, and eventually deletion variants became predominant, leading to the hypothesis that ORF8 was an evolutionary hot spot for adaptation of SARS-CoV to humans. However, due to the successful control of the SARS epidemic, the importance of these deletions for the epidemiological fitness of SARS-CoV in humans could not be established. The emergence of multiple SARS-CoV-2 strains with ORF8 deletions, combined with evidence of a robust immune response to ORF8, suggests that the lack of ORF8 may assist with host immune evasion. In addition to providing a key insight into the evolutionary behavior of SARS-CoV-2 as the virus adapts to its new human hosts, the emergence of ORF8 deletion variants may also impact vaccination strategies.</jats:p>

収録刊行物

  • mBio

    mBio 11 (4), e01610-20-, 2020-08-25

    American Society for Microbiology

被引用文献 (6)*注記

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