Curcumin-Artemisinin Combination Therapy for Malaria
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- Dalavaikodihalli Nanjaiah Nandakumar
- Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India
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- Viswanathan Arun Nagaraj
- Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India
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- Palakkod Govindan Vathsala
- Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India
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- Pundi Rangarajan
- Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India
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- Govindarajan Padmanaban
- Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India
Abstract
<jats:title>ABSTRACT</jats:title> <jats:p> Artemisinin and curcumin show an additive interaction in killing <jats:italic>Plasmodium falciparum</jats:italic> in culture. In vivo, 3 oral doses of curcumin following a single injection of α,β-arteether to <jats:italic>Plasmodium berghei</jats:italic> -infected mice are able to prevent recrudescence due to α,β-arteether monotherapy and ensure almost 100% survival of the animals. </jats:p>
Journal
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- Antimicrobial Agents and Chemotherapy
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Antimicrobial Agents and Chemotherapy 50 (5), 1859-1860, 2006-05
American Society for Microbiology
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Details 詳細情報について
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- CRID
- 1362262944069962368
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- ISSN
- 10986596
- 00664804
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- Data Source
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- Crossref