DNA vaccine protection against SARS-CoV-2 in rhesus macaques

DOI Web Site Web Site 被引用文献13件
  • Jingyou Yu
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Lisa H. Tostanoski
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Lauren Peter
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Noe B. Mercado
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Katherine McMahan
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Shant H. Mahrokhian
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Joseph P. Nkolola
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Jinyan Liu
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Zhenfeng Li
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Abishek Chandrashekar
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • David R. Martinez
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Carolin Loos
    Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Caroline Atyeo
    Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Stephanie Fischinger
    Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • John S. Burke
    Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Matthew D. Slein
    Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Yuezhou Chen
    Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Adam Zuiani
    Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Felipe J. N. Lelis
    Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Meghan Travers
    Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Shaghayegh Habibi
    Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Laurent Pessaint
    Bioqual, Rockville, MD 20852, USA.
  • Alex Van Ry
    Bioqual, Rockville, MD 20852, USA.
  • Kelvin Blade
    Bioqual, Rockville, MD 20852, USA.
  • Renita Brown
    Bioqual, Rockville, MD 20852, USA.
  • Anthony Cook
    Bioqual, Rockville, MD 20852, USA.
  • Brad Finneyfrock
    Bioqual, Rockville, MD 20852, USA.
  • Alan Dodson
    Bioqual, Rockville, MD 20852, USA.
  • Elyse Teow
    Bioqual, Rockville, MD 20852, USA.
  • Jason Velasco
    Bioqual, Rockville, MD 20852, USA.
  • Roland Zahn
    Janssen Vaccines & Prevention BV, Leiden, Netherlands.
  • Frank Wegmann
    Janssen Vaccines & Prevention BV, Leiden, Netherlands.
  • Esther A. Bondzie
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Gabriel Dagotto
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Makda S. Gebre
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Xuan He
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Catherine Jacob-Dolan
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Marinela Kirilova
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Nicole Kordana
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Zijin Lin
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Lori F. Maxfield
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Felix Nampanya
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Ramya Nityanandam
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • John D. Ventura
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Huahua Wan
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Yongfei Cai
    Children’s Hospital, Boston, MA 02115, USA.
  • Bing Chen
    Children’s Hospital, Boston, MA 02115, USA.
  • Aaron G. Schmidt
    Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Duane R. Wesemann
    Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Ralph S. Baric
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Galit Alter
    Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Hanne Andersen
    Bioqual, Rockville, MD 20852, USA.
  • Mark G. Lewis
    Bioqual, Rockville, MD 20852, USA.
  • Dan H. Barouch
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

説明

<jats:title>Prototype DNA vaccines for SARS-CoV-2</jats:title> <jats:p> The development of a vaccine to protect against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an urgent biomedical need. Yu <jats:italic>et al.</jats:italic> designed a series of prototype DNA vaccines against the SARS-CoV-2 spike protein, which is used by the virus to bind and invade human cells. Analysis of the vaccine candidates in rhesus macaques showed that animals developed protective humoral and cellular immune responses when challenged with the virus. Neutralizing antibody titers were also observed at levels similar to those seen in humans who have recovered from SARS-CoV-2 infection. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6505" page="806" related-article-type="in-this-issue" vol="369" xlink:href="10.1126/science.abc6284">806</jats:related-article> </jats:p>

収録刊行物

  • Science

    Science 369 (6505), 806-811, 2020-08-14

    American Association for the Advancement of Science (AAAS)

被引用文献 (13)*注記

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