HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1
書誌事項
- 公開日
- 2008-10-01
- DOI
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- 10.1101/gad.1674108
- 公開者
- Cold Spring Harbor Laboratory
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説明
<jats:p>HBO1 histone acetylase is important for DNA replication licensing. In human cells, HBO1 associates with replication origins specifically during the G1 phase of the cell cycle in a manner that depends on the replication licensing factor Cdt1, but is independent of the Cdt1 repressor Geminin. HBO1 directly interacts with Cdt1, and it enhances Cdt1-dependent rereplication. Thus, HBO1 plays a direct role at replication origins as a coactivator of the Cdt1 licensing factor. As HBO1 is also a transcriptional coactivator, it has the potential to integrate internal and external stimuli to coordinate transcriptional responses with initiation of DNA replication.</jats:p>
収録刊行物
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- Genes & Development
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Genes & Development 22 (19), 2633-2638, 2008-10-01
Cold Spring Harbor Laboratory
