Hyperglycemia Associated With High, Continuous Infusion Rates of Total Parenteral Nutrition Dextrose

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<jats:title>ABSTRACT</jats:title><jats:p>A retrospective study was performed to determine whether there is an increased incidence of hyperglycemia in patients not predisposed to hyperglycemia (n = 102) who receive total parenteral nutrition (TPN) dextrose in excess of 4 to 5 mg/kg/min. Of the 37 subjects administered dextrose at >5 mg/kg/min, 18 exhibited hyperglycemia. None did so who received dextrose at ≤4 mg/kg/min (n = 19). TPN dextrose infusion rate was positively correlated with blood glucose concentration, over and above other variables considered in a multiple regression, including kcal/kg administered, furosemide or dopamine use, gender, age, or diagnosis. Thus, TPN dextrose infusion rates > 4 to 5 mg/kg/min increase risk of hyperglycemia.</jats:p>

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