<i>Cryptococcus neoformans</i>Glucuronoxylomannan and Sterylglucoside Are Required for Host Protection in an Animal Vaccination Model

DOI Web Site 2 Citations
  • Ana Caroline Colombo
    Instituto de Bioquímica Médica (IBqM), Rio de Janeiro, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
  • Antonella Rella
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
  • Tyler Normile
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
  • Luna S. Joffe
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
  • Patricia M. Tavares
    Instituto de Microbiologia Paulo de Góes (IMPG), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
  • Glauber R. de S. Araújo
    Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
  • Susana Frases
    Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
  • Erika P. Orner
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
  • Amir M. Farnoud
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
  • Bettina C. Fries
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
  • Brian Sheridan
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
  • Leonardo Nimrichter
    Instituto de Microbiologia Paulo de Góes (IMPG), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
  • Marcio L. Rodrigues
    Instituto de Microbiologia Paulo de Góes (IMPG), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
  • Maurizio Del Poeta
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
  • Tamara L. Doering
    editor

Abstract

<jats:p>The number of deaths from cryptococcal meningitis is around 180,000 per year. The disease is the second leading cause of mortality among individuals with AIDS. Antifungal treatment is costly and associated with adverse effects and resistance, evidencing the urgency of development of both therapeutic and prophylactic tools. Here we demonstrate the key roles of polysaccharide- and glycolipid-containing structures in a vaccination model to prevent cryptococcosis.</jats:p>

Journal

  • mBio

    mBio 10 (2), 2019-04-30

    American Society for Microbiology

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