Mutation in the NDUFS4 gene of complex I abolishes cAMP‐dependent activation of the complex in a child with fatal neurological syndrome
Abstract
<jats:p>Evidence is presented showing that in a patient with fatal neurological syndrome, the homozygous 5 bp duplication in the cDNA of the NDUFS4 18 kDa subunit of complex I abolishes cAMP‐dependent phosphorylation of this protein and activation of the complex. These findings show for the first time that human complex I is regulated via phosphorylation of the subunit encoded by the NDUFS4 gene.</jats:p>
Journal
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- FEBS Letters
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FEBS Letters 489 (2-3), 259-262, 2001-01-31
Wiley
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Details 詳細情報について
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- CRID
- 1362262944107018880
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- ISSN
- 18733468
- 00145793
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- Data Source
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- Crossref