Phagocytosis imprints heterogeneity in tissue-resident macrophages

DOI PDF 被引用文献8件
  • Noelia A-Gonzalez
    Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain 1
  • Juan A. Quintana
    Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain 1
  • Susana García-Silva
    Microenvironment and Metastasis Group, Molecular Oncology Program, Spanish National Cancer Research Centre, 28029 Madrid, Spain 3
  • Marina Mazariegos
    Microenvironment and Metastasis Group, Molecular Oncology Program, Spanish National Cancer Research Centre, 28029 Madrid, Spain 3
  • Arturo González de la Aleja
    Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain 1
  • José A. Nicolás-Ávila
    Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain 1
  • Wencke Walter
    Area of Myocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain 2
  • Jose M. Adrover
    Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain 1
  • Georgiana Crainiciuc
    Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain 1
  • Vijay K. Kuchroo
    Evergrande Center for Immunological Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115 4
  • Carla V. Rothlin
    Immunobiology Department, Yale School of Medicine, New Haven, CT 06510 5
  • Héctor Peinado
    Microenvironment and Metastasis Group, Molecular Oncology Program, Spanish National Cancer Research Centre, 28029 Madrid, Spain 3
  • Antonio Castrillo
    Instituto de Investigaciones Biomédicas “Alberto Sols,” Consejo Superior de Investigaciones Científicas de Madrid, Unidad de Biomedicina (Unidad Asociada al CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias de laUniversidad de Las Palmas de Gran Canaria, 35001 Las Palmas, Spain 6
  • Mercedes Ricote
    Area of Myocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain 2
  • Andrés Hidalgo
    Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain 1

説明

<jats:p>Tissue-resident macrophages display varying phenotypic and functional properties that are largely specified by their local environment. One of these functions, phagocytosis, mediates the natural disposal of billions of cells, but its mechanisms and consequences within living tissues are poorly defined. Using a parabiosis-based strategy, we identified and isolated macrophages from multiple tissues as they phagocytosed blood-borne cellular material. Phagocytosis was circadianally regulated and mediated by distinct repertoires of receptors, opsonins, and transcription factors in macrophages from each tissue. Although the tissue of residence defined the core signature of macrophages, phagocytosis imprinted a distinct antiinflammatory profile. Phagocytic macrophages expressed CD206, displayed blunted expression of Il1b, and supported tissue homeostasis. Thus, phagocytosis is a source of macrophage heterogeneity that acts together with tissue-derived factors to preserve homeostasis.</jats:p>

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