Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury

DOI PDF XML 被引用文献2件
  • Xing Chen
    The Fourth Hospital of Tianjin, Tianjin 300222, China
  • Qi Liu
    Tianjin Medical University, Tianjin 300070, China
  • Dawei Wang
    Tianjin Medical University, Tianjin 300070, China
  • Shihai Feng
    The Fourth Hospital of Tianjin, Tianjin 300222, China
  • Yongjian Zhao
    The Fourth Hospital of Tianjin, Tianjin 300222, China
  • Yun Shi
    The Fourth Hospital of Tianjin, Tianjin 300222, China
  • Qun Liu
    The Fourth Hospital of Tianjin, Tianjin 300222, China

書誌事項

公開日
2015
権利情報
  • http://creativecommons.org/licenses/by/3.0/
DOI
  • 10.1155/2015/106836
公開者
Wiley

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説明

<jats:p><jats:italic>Objective</jats:italic>. To explore the protective effects of hydrogen-rich saline on rats with smoke inhalation injury.<jats:italic>Methods</jats:italic>. 36 healthy male Sprague-Dawley rats were randomly divided into 3 groups (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>12</mml:mn></mml:math>per group): sham group (S), inhalation injury plus normal saline treatment group (I+NS), and inhalation injury plus hydrogen-rich saline treatment group (I+HS). 30 min after injury, normal saline and hydrogen-rich saline were injected intraperitoneally (5 mL/kg) in I+NS group and I+HS group, respectively. All rats were euthanized and blood and organ specimens were collected for determination 24 h after inhalation injury.<jats:italic>Results</jats:italic>. Tumor necrosis factor-alpha (TNF-<jats:italic>α</jats:italic>) levels, malondialdehyde (MDA) concentrations, nuclear factor kappa B (NF-<jats:italic>κ</jats:italic>B) p65 expression, and apoptosis index (AI) in I+HS group were significantly decreased (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:math>), while superoxide dismutase (SOD) activities were increased compared with those in I+NS group; and a marked improvement in alveolar structure was also found after hydrogen-rich saline treatment.<jats:italic>Conclusions</jats:italic>. Hydrogen-rich saline treatment exerts protective effects in acute lung injury induced by inhalation injury, at least in part through the activation of anti-inflammatory and antioxidant pathways and inhibition of apoptosis.</jats:p>

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