Angiogenin gene-race interaction for resting and exercise BP phenotypes: the HERITAGE Family Study

DOI Web Site 被引用文献1件
  • Miguel A. Rivera
    Departments of Physiology and Physical Medicine, Rehabilitation and Sports Medicine, University of Puerto Rico School of Medicine, San Juan, Puerto Rico 00936;
  • Marcos Echegaray
    Departments of Physiology and Physical Medicine, Rehabilitation and Sports Medicine, University of Puerto Rico School of Medicine, San Juan, Puerto Rico 00936;
  • Tuomo Rankinen
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808 – 4124;
  • Louis Pérusse
    Physical Activity Sciences Laboratory, Laval University, Québec, Canada G1K 7P4;
  • Treva Rice
    Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110;
  • Jacques Gagnon
    Physical Activity Sciences Laboratory, Laval University, Québec, Canada G1K 7P4;
  • Arthur S. Leon
    School of Kinesiology and Leisure Studies, University of Minnesota, Minneapolis, Minnesota 55455;
  • James S. Skinner
    Department of Kinesiology, Indiana University, Bloomington, Indiana 47405; and
  • Jack H. Wilmore
    Department of Health and Kinesiology, Texas A&M University, College Station, Texas 77843 – 4243
  • D. C. Rao
    Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110;
  • Claude Bouchard
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808 – 4124;

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<jats:p>We examined the association between an angiogenin gene polymorphism and blood pressure (BP) at rest and in response to acute exercise before and after a 20-wk endurance-training program. Subjects were 737 normotensive and borderline hypertensive subjects (257 black and 480 white). The polymorphism was detected by PCR and digestion with AvaII, yielding an allele of 253 bp or a rare allele of 194 + 59 bp. Resting and exercise [50 W; 60, 80, and 100% of maximal O<jats:sub>2</jats:sub>consumption (V˙o<jats:sub>2 max</jats:sub>)] systolic (SBP) and diastolic BP were determined before and after training. Among blacks, adjusted SBP in the sedentary state was significantly lower in carriers of the rare allele at rest and exercise intensities of 60, 80, and 100% ofV˙o<jats:sub>2 max</jats:sub>. In the trained state, carriers of the rare allele had a significantly ( P < 0.05) lower SBP than did noncarriers at rest and at 80 and 100% ofV˙o<jats:sub>2 max</jats:sub>. The genotypic effect observed among blacks was not evident among whites. Furthermore, change in BP (after − before) was not significantly associated with the genotype. In conclusion, the angiogenin gene AvaII polymorphism is associated with a lower SBP at rest and in response to acute high-intensity exercise in blacks but not in whites.</jats:p>

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