Effect of Intravenous Tenecteplase Dose on Cerebral Reperfusion Before Thrombectomy in Patients With Large Vessel Occlusion Ischemic Stroke

Bruce C. V. Campbell, Peter J. Mitchell, Leonid Churilov, Nawaf Yassi, Timothy J. Kleinig, Richard J. Dowling, Bernard Yan, Steven J. Bush, Vincent Thijs, Rebecca Scroop, Marion Simpson, Mark Brooks, Hamed Asadi, Teddy Y. Wu, Darshan G. Shah, Tissa Wijeratne, Henry Zhao, Fana Alemseged, Felix Ng, Peter Bailey, Henry Rice, Laetitia de Villiers, Helen M. Dewey, Philip M. C. Choi, Helen Brown, Kendal Redmond, David Leggett, John N. Fink, Wayne Collecutt, Thomas Kraemer, Martin Krause, Dennis Cordato, Deborah Field, Henry Ma, Bill O’Brien, Benjamin Clissold, Ferdinand Miteff, Anna Clissold, Geoffrey C. Cloud, Leslie E. Bolitho, Luke Bonavia, Arup Bhattacharya, Alistair Wright, Abul Mamun, Fintan O’Rourke, John Worthington, Andrew A. Wong, Christopher R. Levi, Christopher F. Bladin, Gagan Sharma, Patricia M. Desmond, Mark W. Parsons, Geoffrey A. Donnan, Stephen M. Davis, James Taylor, Craig Kurunawai, Edmund Cheong, Anna Balabanski, Michael J Waters, Jackson Harvey, Lavenia Cagi, Nicholas Chia, Anthony Khoo, Roy Drew, Jennifer Cranefield, Thomas J Oxley, Cameron Williams, Edrich Rodrigues, Patrick Salvaris, Angela Dos Santos, Jo-Lyn Ng, Skye Coote, Carolyn Beltrame, Elizabeth Mackey, Kanaga Lagma, Amy McDonald, David Jackson, Jessica Tsoleridis, Lauren Pesavento, Ashu Jhamb, Amy Brodtmann, Alexandra Warwick, Bronwyn Coulton, Dennis Young, Justin Whitley, Carol Bendall, Hans TH Tu, Sherisse Celestino, Essie Low, Arman Sabet, Sachin Mishra, Berzenn Urbi, Tanya Frost, Jessie Chen, Siew Kar Chen, Melissa Y Tang, Kara Nowak, Rodrigo Martins, Channa Senanayake, Charmaine H Yam, Daniel Barber, Francesca M Bridge, Joseph ZW Wong, Grace Thomas, Jennifer Liu, Naila Pachani, Rose Lee, Ramesh Sahathevan, Casey Hair, Timothy J Harrington, Brendan Steinfort, Kenneth Faulder, Susan Day, Allan J McDougall, Cecilia Cappelen-Smith, Jason Wenderoth, Andrew Cheung, Nathan Manning, Andrew Moey, Vanessa Maxwell, Thanh Phan, Shaloo Singhal, John Ly, Winston Chong, Ronil V Chandra, Lee-Anne Slater, James Evans, Deborah Alchin, Paul Talman, Cameron Shaw, Abhishek Malhotra, Rohitha Makonahalli, Neil Spratt, Carlos Garcia-Esperon, Lara Kaauwai, Patrick Groot, Anoop Madan, Carlos Chung, Andrea Moore, Robert Krones, Nancy Bilkhu, Helen Haines, Franz Eversheim, Erin Ray, Tessa Coupland, Timothy Ang, Stephen Winters, David Brunacci, Geoffrey Parker, Kylie Tastula, Claire Muller, Alan Coulthard, John Clouston, Ken Mitchell, Kate Mahady, Yvonne Liu, Ye Min Kuang, Aileen Wu, Karen Smith, Michael Stephenson, Emily Andrew, Matthew Ligtermoet, Matthew Lee-Archer, John N Fink, James Beharry, Andrew Laing, Martin Krauss, Jane Eagle, Gerhard Uys, Lauren Arthurson, Krishna Mandaleson, Anne Van Berkel, Rohan Grimley, Wayne Skoien, Neil Mahant, P. Alan Barber, Ben McGuinness, Ayton Hope, Stefan Brew, Maurice Moriarty, Lily Zhao, Michele Sallaberger, Barry Snow, John Kolbe, Richard Stark, John King, Richard Macdonnell, John Attia, Cate D'Este

doi:10.1001/jama.2020.1511

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Effect of Intravenous Tenecteplase Dose on Cerebral Reperfusion Before Thrombectomy in Patients With Large Vessel Occlusion Ischemic Stroke

DOI PDF 2 Citations

Bruce C. V. Campbell

Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Peter J. Mitchell

Department of Radiology, the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Leonid Churilov

Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Nawaf Yassi

Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Timothy J. Kleinig

Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Richard J. Dowling

Department of Radiology, the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Bernard Yan

Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Steven J. Bush

Department of Radiology, the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Vincent Thijs

The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia
Rebecca Scroop

Department of Radiology, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Marion Simpson

Department of Neurology, Austin Hospital, Austin Health, Heidelberg, Victoria, Australia
Mark Brooks

Department of Radiology, Austin Hospital, Austin Health, Heidelberg, Victoria, Australia
Hamed Asadi

The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia
Teddy Y. Wu

Department of Neurology, Christchurch Hospital, Christchurch, New Zealand
Darshan G. Shah

Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia
Tissa Wijeratne

Melbourne Medical School, Department of Medicine and Neurology, The University of Melbourne and Western Health, Sunshine Hospital, St Albans Victoria, Australia
Henry Zhao

Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Fana Alemseged

Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Felix Ng

Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Peter Bailey

Department of Neurology, Gold Coast University Hospital, Southport, Queensland, Australia
Henry Rice

Department of Radiology, Gold Coast University Hospital, Southport, Queensland, Australia
Laetitia de Villiers

Department of Radiology, Gold Coast University Hospital, Southport, Queensland, Australia
Helen M. Dewey

Eastern Health and Eastern Health Clinical School, Department of Neurosciences, Monash University, Clayton, Victoria, Australia
Philip M. C. Choi

Eastern Health and Eastern Health Clinical School, Department of Neurosciences, Monash University, Clayton, Victoria, Australia
Helen Brown

Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia
Kendal Redmond

Department of Radiology, Princess Alexandra Hospital, Brisbane, Queensland, Australia
David Leggett

Department of Radiology, Princess Alexandra Hospital, Brisbane, Queensland, Australia
John N. Fink

Department of Neurology, Christchurch Hospital, Christchurch, New Zealand
Wayne Collecutt

Department of Radiology, Christchurch Hospital, Christchurch, New Zealand
Thomas Kraemer

Department of Medicine, Ballarat Base Hospital, Ballarat, Victoria, Australia
Martin Krause

Department of Neurology, Royal North Shore Hospital and Kolling Institute, University of Sydney, St Leonards, New South Wales, Australia
Dennis Cordato

Department of Neurology, Liverpool Hospital, Liverpool, New South Wales, Australia
Deborah Field

Department of Neurology, Lyell McEwin Hospital, Adelaide, South Australia, Australia
Henry Ma

School of Clinical Sciences, Department of Medicine, Monash University, Clayton, Victoria, Australia
Bill O’Brien

Department of Neurology, Gosford Hospital, Gosford, New South Wales, Australia
Benjamin Clissold

Department of Neurology, University Hospital Geelong, Deakin University, Geelong, Victoria, Australia
Ferdinand Miteff

Department of Neurology, Priority Research Centre for Brain and Mental Health Research, John Hunter Hospital, University of Newcastle, Newcastle, New South Wales, Australia
Anna Clissold

Department of Medicine, Southwest Healthcare, Warrnambool, Victoria, Australia
Geoffrey C. Cloud

Department of Neurology, Alfred Hospital, Prahran, Victoria, Australia
Leslie E. Bolitho

Department of Medicine, Northeast Health, Wangaratta, Victoria, Australia
Luke Bonavia

Department of Medicine, Albury Base Hospital, Albury, New South Wales, Australia
Arup Bhattacharya

Department of Medicine, Goulburn Valley Health, Shepparton, Victoria, Australia
Alistair Wright

Department of Medicine, Latrobe Regional Health, Traralgon, Victoria, Australia
Abul Mamun

Department of Medicine, Campbelltown Hospital, Campbelltown, New South Wales, Australia
Fintan O’Rourke

Department of Aged Care and Rehabilitation, Bankstown-Lidcombe Hospital, Bankstown, New South Wales, Australia
John Worthington

Department of Neurology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
Andrew A. Wong

Department of Neurology, Royal Brisbane and Women’s Hospital and the University of Queensland, Brisbane, Queensland, Australia
Christopher R. Levi

Maridulu budyari gumal, The Sydney Partnership for Health Education Research & Enterprise (SPHERE), University of New South Wales, Sydney, Australia
Christopher F. Bladin

The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia
Gagan Sharma

Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Patricia M. Desmond

Department of Radiology, the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Mark W. Parsons

Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Geoffrey A. Donnan

Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Stephen M. Davis

Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
James Taylor

for the EXTEND-IA TNK Part 2 investigators
Craig Kurunawai

for the EXTEND-IA TNK Part 2 investigators
Edmund Cheong

for the EXTEND-IA TNK Part 2 investigators
Anna Balabanski

for the EXTEND-IA TNK Part 2 investigators
Michael J Waters

for the EXTEND-IA TNK Part 2 investigators
Jackson Harvey

for the EXTEND-IA TNK Part 2 investigators
Lavenia Cagi

for the EXTEND-IA TNK Part 2 investigators
Nicholas Chia

for the EXTEND-IA TNK Part 2 investigators
Anthony Khoo

for the EXTEND-IA TNK Part 2 investigators
Roy Drew

for the EXTEND-IA TNK Part 2 investigators
Jennifer Cranefield

for the EXTEND-IA TNK Part 2 investigators
Thomas J Oxley

for the EXTEND-IA TNK Part 2 investigators
Cameron Williams

for the EXTEND-IA TNK Part 2 investigators
Edrich Rodrigues

for the EXTEND-IA TNK Part 2 investigators
Patrick Salvaris

for the EXTEND-IA TNK Part 2 investigators
Angela Dos Santos

for the EXTEND-IA TNK Part 2 investigators
Jo-Lyn Ng

for the EXTEND-IA TNK Part 2 investigators
Skye Coote

for the EXTEND-IA TNK Part 2 investigators
Carolyn Beltrame

for the EXTEND-IA TNK Part 2 investigators
Elizabeth Mackey

for the EXTEND-IA TNK Part 2 investigators
Kanaga Lagma

for the EXTEND-IA TNK Part 2 investigators
Amy McDonald

for the EXTEND-IA TNK Part 2 investigators
David Jackson

for the EXTEND-IA TNK Part 2 investigators
Jessica Tsoleridis

for the EXTEND-IA TNK Part 2 investigators
Lauren Pesavento

for the EXTEND-IA TNK Part 2 investigators
Ashu Jhamb

for the EXTEND-IA TNK Part 2 investigators
Amy Brodtmann

for the EXTEND-IA TNK Part 2 investigators
Alexandra Warwick

for the EXTEND-IA TNK Part 2 investigators
Bronwyn Coulton

for the EXTEND-IA TNK Part 2 investigators
Dennis Young

for the EXTEND-IA TNK Part 2 investigators
Justin Whitley

for the EXTEND-IA TNK Part 2 investigators
Carol Bendall

for the EXTEND-IA TNK Part 2 investigators
Hans TH Tu

for the EXTEND-IA TNK Part 2 investigators
Sherisse Celestino

for the EXTEND-IA TNK Part 2 investigators
Essie Low

for the EXTEND-IA TNK Part 2 investigators
Arman Sabet

for the EXTEND-IA TNK Part 2 investigators
Sachin Mishra

for the EXTEND-IA TNK Part 2 investigators
Berzenn Urbi

for the EXTEND-IA TNK Part 2 investigators
Tanya Frost

for the EXTEND-IA TNK Part 2 investigators
Jessie Chen

for the EXTEND-IA TNK Part 2 investigators
Siew Kar Chen

for the EXTEND-IA TNK Part 2 investigators
Melissa Y Tang

for the EXTEND-IA TNK Part 2 investigators
Kara Nowak

for the EXTEND-IA TNK Part 2 investigators
Rodrigo Martins

for the EXTEND-IA TNK Part 2 investigators
Channa Senanayake

for the EXTEND-IA TNK Part 2 investigators
Charmaine H Yam

for the EXTEND-IA TNK Part 2 investigators
Daniel Barber

for the EXTEND-IA TNK Part 2 investigators
Francesca M Bridge

for the EXTEND-IA TNK Part 2 investigators
Joseph ZW Wong

for the EXTEND-IA TNK Part 2 investigators
Grace Thomas

for the EXTEND-IA TNK Part 2 investigators
Jennifer Liu

for the EXTEND-IA TNK Part 2 investigators
Naila Pachani

for the EXTEND-IA TNK Part 2 investigators
Rose Lee

for the EXTEND-IA TNK Part 2 investigators
Ramesh Sahathevan

for the EXTEND-IA TNK Part 2 investigators
Casey Hair

for the EXTEND-IA TNK Part 2 investigators
Timothy J Harrington

for the EXTEND-IA TNK Part 2 investigators
Brendan Steinfort

for the EXTEND-IA TNK Part 2 investigators
Kenneth Faulder

for the EXTEND-IA TNK Part 2 investigators
Susan Day

for the EXTEND-IA TNK Part 2 investigators
Allan J McDougall

for the EXTEND-IA TNK Part 2 investigators
Cecilia Cappelen-Smith

for the EXTEND-IA TNK Part 2 investigators
Jason Wenderoth

for the EXTEND-IA TNK Part 2 investigators
Andrew Cheung

for the EXTEND-IA TNK Part 2 investigators
Nathan Manning

for the EXTEND-IA TNK Part 2 investigators
Andrew Moey

for the EXTEND-IA TNK Part 2 investigators
Vanessa Maxwell

for the EXTEND-IA TNK Part 2 investigators
Thanh Phan

for the EXTEND-IA TNK Part 2 investigators
Shaloo Singhal

for the EXTEND-IA TNK Part 2 investigators
John Ly

for the EXTEND-IA TNK Part 2 investigators
Winston Chong

for the EXTEND-IA TNK Part 2 investigators
Ronil V Chandra

for the EXTEND-IA TNK Part 2 investigators
Lee-Anne Slater

for the EXTEND-IA TNK Part 2 investigators
James Evans

for the EXTEND-IA TNK Part 2 investigators
Deborah Alchin

for the EXTEND-IA TNK Part 2 investigators
Paul Talman

for the EXTEND-IA TNK Part 2 investigators
Cameron Shaw

for the EXTEND-IA TNK Part 2 investigators
Abhishek Malhotra

for the EXTEND-IA TNK Part 2 investigators
Rohitha Makonahalli

for the EXTEND-IA TNK Part 2 investigators
Neil Spratt

for the EXTEND-IA TNK Part 2 investigators
Carlos Garcia-Esperon

for the EXTEND-IA TNK Part 2 investigators
Lara Kaauwai

for the EXTEND-IA TNK Part 2 investigators
Patrick Groot

for the EXTEND-IA TNK Part 2 investigators
Anoop Madan

for the EXTEND-IA TNK Part 2 investigators
Carlos Chung

for the EXTEND-IA TNK Part 2 investigators
Andrea Moore

for the EXTEND-IA TNK Part 2 investigators
Robert Krones

for the EXTEND-IA TNK Part 2 investigators
Nancy Bilkhu

for the EXTEND-IA TNK Part 2 investigators
Helen Haines

for the EXTEND-IA TNK Part 2 investigators
Franz Eversheim

for the EXTEND-IA TNK Part 2 investigators
Erin Ray

for the EXTEND-IA TNK Part 2 investigators
Tessa Coupland

for the EXTEND-IA TNK Part 2 investigators
Timothy Ang

for the EXTEND-IA TNK Part 2 investigators
Stephen Winters

for the EXTEND-IA TNK Part 2 investigators
David Brunacci

for the EXTEND-IA TNK Part 2 investigators
Geoffrey Parker

for the EXTEND-IA TNK Part 2 investigators
Kylie Tastula

for the EXTEND-IA TNK Part 2 investigators
Claire Muller

for the EXTEND-IA TNK Part 2 investigators
Alan Coulthard

for the EXTEND-IA TNK Part 2 investigators
John Clouston

for the EXTEND-IA TNK Part 2 investigators
Ken Mitchell

for the EXTEND-IA TNK Part 2 investigators
Kate Mahady

for the EXTEND-IA TNK Part 2 investigators
Yvonne Liu

for the EXTEND-IA TNK Part 2 investigators
Ye Min Kuang

for the EXTEND-IA TNK Part 2 investigators
Aileen Wu

for the EXTEND-IA TNK Part 2 investigators
Karen Smith

for the EXTEND-IA TNK Part 2 investigators
Michael Stephenson

for the EXTEND-IA TNK Part 2 investigators
Emily Andrew

for the EXTEND-IA TNK Part 2 investigators
Matthew Ligtermoet

for the EXTEND-IA TNK Part 2 investigators
Matthew Lee-Archer

for the EXTEND-IA TNK Part 2 investigators
John N Fink

for the EXTEND-IA TNK Part 2 investigators
James Beharry

for the EXTEND-IA TNK Part 2 investigators
Andrew Laing

for the EXTEND-IA TNK Part 2 investigators
Martin Krauss

for the EXTEND-IA TNK Part 2 investigators
Jane Eagle

for the EXTEND-IA TNK Part 2 investigators
Gerhard Uys

for the EXTEND-IA TNK Part 2 investigators
Lauren Arthurson

for the EXTEND-IA TNK Part 2 investigators
Krishna Mandaleson

for the EXTEND-IA TNK Part 2 investigators
Anne Van Berkel

for the EXTEND-IA TNK Part 2 investigators
Rohan Grimley

for the EXTEND-IA TNK Part 2 investigators
Wayne Skoien

for the EXTEND-IA TNK Part 2 investigators
Neil Mahant

for the EXTEND-IA TNK Part 2 investigators
P. Alan Barber

for the EXTEND-IA TNK Part 2 investigators
Ben McGuinness

for the EXTEND-IA TNK Part 2 investigators
Ayton Hope

for the EXTEND-IA TNK Part 2 investigators
Stefan Brew

for the EXTEND-IA TNK Part 2 investigators
Maurice Moriarty

for the EXTEND-IA TNK Part 2 investigators
Lily Zhao

for the EXTEND-IA TNK Part 2 investigators
Michele Sallaberger

for the EXTEND-IA TNK Part 2 investigators
Barry Snow

for the EXTEND-IA TNK Part 2 investigators
John Kolbe

for the EXTEND-IA TNK Part 2 investigators
Richard Stark

for the EXTEND-IA TNK Part 2 investigators
John King

for the EXTEND-IA TNK Part 2 investigators
Richard Macdonnell

for the EXTEND-IA TNK Part 2 investigators
John Attia

for the EXTEND-IA TNK Part 2 investigators
Cate D'Este

for the EXTEND-IA TNK Part 2 investigators

Bibliographic Information

Other Title

The EXTEND-IA TNK Part 2 Randomized Clinical Trial

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Journal

JAMA

JAMA 323 (13), 1257-, 2020-04-07

American Medical Association (AMA)

Citations (2)*help

Details 詳細情報について

CRID

1362262944306914560
DOI

10.1001/jama.2020.1511
ISSN

00987484
Web Site

https://jamanetwork.com/journals/jama/articlepdf/2761799/jama_campbell_2020_oi_200018_1644866873.2431.pdf
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