Oxidative Stress Parameters in Saliva and Its Association with Periodontal Disease and Types of Bacteria

  • Jose Manuel Almerich-Silla
    Department d’Estomatología, Facultat de Medicina y Odontología, Universitat de València, C/ Gascó Oliag 1, 46010 Valencia, Spain
  • Jose María Montiel-Company
    Department d’Estomatología, Facultat de Medicina y Odontología, Universitat de València, C/ Gascó Oliag 1, 46010 Valencia, Spain
  • Sara Pastor
    Fundación Investigación Hospital Clínico Universitario de Valencia, Instituto de Investigación Sanitaria INCLIVA, C/ Menéndez y Pelayo 4, 46010 Valencia, Spain
  • Felipe Serrano
    Fundación Investigación Hospital Clínico Universitario de Valencia, Instituto de Investigación Sanitaria INCLIVA, C/ Menéndez y Pelayo 4, 46010 Valencia, Spain
  • Miriam Puig-Silla
    Department d’Estomatología, Facultat de Medicina y Odontología, Universitat de València, C/ Gascó Oliag 1, 46010 Valencia, Spain
  • Francisco Dasí
    Fundación Investigación Hospital Clínico Universitario de Valencia, Instituto de Investigación Sanitaria INCLIVA, C/ Menéndez y Pelayo 4, 46010 Valencia, Spain

抄録

<jats:p><jats:italic>Objective</jats:italic>. To determine the association between oxidative stress parameters with periodontal disease, bleeding, and the presence of different periodontal bacteria.<jats:italic>Methods</jats:italic>. A cross-sectional study in a sample of eighty-six patients, divided into three groups depending on their periodontal status. Thirty-three with chronic periodontitis, sixteen with gingivitis, and thirty-seven with periodontal healthy as control. Oxidative stress biomarkers (8-OHdG and MDA), total antioxidant capacity (TAOC), and the activity of two antioxidant enzymes (GPx and SOD) were determined in saliva. Subgingival plaque samples were obtained from the deepest periodontal pocket and PCR was used to determine the presence of the 6 fimA genotypes of<jats:italic>Porphyromonas gingivalis</jats:italic>,<jats:italic>Aggregatibacter actinomycetemcomitans</jats:italic>,<jats:italic>Tannerella forsythia</jats:italic>, and<jats:italic>Treponema denticola</jats:italic>.<jats:italic>Results</jats:italic>. Periodontal disease was found to be associated with increased oxidative stress parameter levels. These levels rose according to the number and type of different periodontal bacteria found in the periodontal pockets. The presence of different types of periodontal bacteria is predictive independent variables in linear regresion models of oxidative stress parameters as dependent variable, above all 8-OHdG.<jats:italic>Conclusions</jats:italic>. Oxidative stress parameter levels are correlated with the presence of different types of bacteria. Determination of these levels and periodontal bacteria could be a potent tool for controlling periodontal disease development.</jats:p>

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