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- K Ogasawara
- Japanese Red Cross Tokyo Metropolitan Blood Center.
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- J Ueki
- Japanese Red Cross Tokyo Metropolitan Blood Center.
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- M Takenaka
- Japanese Red Cross Tokyo Metropolitan Blood Center.
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- K Furihata
- Japanese Red Cross Tokyo Metropolitan Blood Center.
書誌事項
- 公開日
- 1993-08-01
- DOI
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- 10.1182/blood.v82.3.993.993
- 公開者
- American Society of Hematology
この論文をさがす
説明
<jats:title>Abstract</jats:title> <jats:p>We recently examined a case of refractoriness to HLA-matched, ABO- incompatible platelet transfusions. The transfused platelets that were rapidly cleared from the circulation of the recipient expressed an amount of B antigen more than 20 times that expressed by the blood group B platelets that were successfully transfused to the recipient. These observations led us to conduct enzyme-linked immunosorbent assay (ELISA) and immunoblotting studies of the amount of blood A and B antigens expressed on the surface of platelets from randomly selected donors. The donors were clearly classified, according to the amount of A or B antigen expressed on their platelets, into two phenotypes, the high-expression and low-expression phenotypes. By ELISA, 7% of the examined donors were determined as belonging to the high-expression phenotype of either A or B antigen. The high-expression phenotype was independent of secretor phenotype. In transferase activity assay, a donor with high expression of B had increased B transferase activity in her serum, which suggested that the high-expression phenotype might be under the control of the glycosyltransferase gene. Family studies showed a dominant inheritance pattern of the high-expression phenotype. This report provides evidence that the expression of ABH antigens on platelets is genetically determined and that the ABO group should be given some attention in platelet transfusions.</jats:p>
収録刊行物
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- Blood
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Blood 82 (3), 993-999, 1993-08-01
American Society of Hematology