Isolation of T-Lymphotropic Retrovirus Related to HTLV-III/LAV from Wild-Caught African Green Monkeys
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- P. J. Kanki
- Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115
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- J. Alroy
- Department of Pathology, Tufts University School of Medicine and Veterinary Medicine, Boston, Massachusetts 02118
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- M. Essex
- Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115
Description
<jats:p> Present evidence suggests that the acquired immune deficiency syndrome (AIDS) emerged in Central Africa as a new disease in recent decades. This disease has recently approached epidemic proportions in many parts of the world. The etiologic agent of AIDS is believed to be the virus HTLV-III/LAV, which has been proposed as having originated from a recent simian-human transmission in Africa. This report describes the isolation of a designated STLV-III <jats:sub>AGM</jats:sub> retrovirus closely related to HTLV-III/LAV from seven healthy wild-caught African Green monkeys ( <jats:italic>Cercopithecus aethiops</jats:italic> ) that showed the presence of antibodies designated STLV-III <jats:sub>AGM</jats:sub> . In vitro growth characteristics, ultrastructural morphology, and major proteins of 160,000 kilodaltons (kD), 120 kD, 55 kD, and 24 kD are similar to and cross-reactive with the analogous antigens of HTLV-III/LAV. The use of these serologic markers in the detection of STLV-III <jats:sub>AGM</jats:sub> -infected monkeys may be important in assuring the continued safety of a variety of biologic reagents that are derived from these primate species. The existence of a retrovirus closely related to HTLV-III/LAV that naturally infects an African nonhuman primate in the apparent absence of disease may provide a unique model for the study of human AIDS and the development of an effective vaccine. </jats:p>
Journal
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- Science
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Science 230 (4728), 951-954, 1985-11-22
American Association for the Advancement of Science (AAAS)
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Details 詳細情報について
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- CRID
- 1362262944404865920
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- ISSN
- 10959203
- 00368075
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- Data Source
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- Crossref