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- S. B. Goodman
- Department of Orthopaedic Surgery and Division of Immunology and Rheumatology, Stanford University Medical Center, Stanford, CA, USA
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- T. Ma
- Department of Orthopaedic Surgery and Division of Immunology and Rheumatology, Stanford University Medical Center, Stanford, CA, USA
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- M. Genovese
- Department of Orthopaedic Surgery and Division of Immunology and Rheumatology, Stanford University Medical Center, Stanford, CA, USA
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- R. Lane Smith
- Department of Orthopaedic Surgery and Division of Immunology and Rheumatology, Stanford University Medical Center, Stanford, CA, USA
説明
<jats:p> Non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed medications for relief of pain and inflammation. Recent animal studies using models of fracture healing and bone ingrowth suggest that NSAIDs (both non-selective NSAIDs and selective COX-2 inhibitors) adversely affect these bone-related processes. The dose and time-relationships of these medications and their resulting effects on bone have not yet been fully elucidated. Furthermore, whether COX-2 inhibitors and non-selective NSAIDs lead to clinically relevant adverse effects on bone healing in humans is unknown. </jats:p>
収録刊行物
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- International Journal of Immunopathology and Pharmacology
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International Journal of Immunopathology and Pharmacology 16 (3), 201-205, 2003-09
SAGE Publications