Identification and distribution of tryptophan hydroxylase (TPH)-positive neurons in the planarian Dugesia japonica
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説明
We identified a full-length tryptophan hydroxylase (TPH) gene of planarian Dugesia japonica from a head EST database, and named it DjTPH. Based on whole-mount in situ hybridization and immunofluorescence analyses, DjTPH mRNA and protein were mainly expressed in the nervous system, especially ventral nerve cords and eye pigment cells. Furthermore, DjTPH immunoreactivity was clearly detected at commissure axonal connections in the ventral nerve cords. 5-HT was significantly decreased in DjTPH-knockdown planarians compared with control animals. These results suggest that DjTPH is required for 5-HT biosynthesis, and DjTPH antibody is a useful marker for serotonergic neurons in planarians.
収録刊行物
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- Neuroscience Research
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Neuroscience Research 59 (1), 101-106, 2007-09
Elsevier BV
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詳細情報 詳細情報について
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- CRID
- 1362262944488021760
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- NII論文ID
- 10024417038
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- NII書誌ID
- AA10641652
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- ISSN
- 01680102
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- PubMed
- 17624455
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- 資料種別
- journal article
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- データソース種別
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- Crossref
- PubMed
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- KAKEN
- OpenAIRE
- LSDB Archive
- Integbio
