Disruption of the head direction cell network impairs the parahippocampal grid cell signal
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- Shawn S. Winter
- Department of Psychological and Brain Sciences, Center for Cognitive Neuroscience, Dartmouth College, Hanover, NH 03755, USA.
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- Benjamin J. Clark
- Department of Psychological and Brain Sciences, Center for Cognitive Neuroscience, Dartmouth College, Hanover, NH 03755, USA.
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- Jeffrey S. Taube
- Department of Psychological and Brain Sciences, Center for Cognitive Neuroscience, Dartmouth College, Hanover, NH 03755, USA.
説明
<jats:title>Are we heading in the right direction?</jats:title> <jats:p> Some neurons, called grid cells, discharge at multiple locations to form a regular pattern that represents the animal's environment. These cells use information about the animal's running speed and direction of movement to constantly update its location. The so-called head direction cells provide the direction-of-movement signal. Winter <jats:italic>et al.</jats:italic> recorded neuronal activity in awake behaving rats. When they disabled the input from the head direction cells, the grid cells lost their normal function. These findings provide experimental confirmation of theoretical predictions that grid cells will no longer exhibit their characteristic firing pattern when the head direction signal is disturbed. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6224" page="870" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.1259591">870</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 347 (6224), 870-874, 2015-02-20
American Association for the Advancement of Science (AAAS)
