Reelin signaling directly affects radial glia morphology and biochemical maturation

DOI PDF 被引用文献11件
  • Eva Hartfuss
    Max-Planck-Institute of Neurobiology, Neuronal Specification, Am Klopferspitz 18a, D-82152 Martinsried, Germany
  • Eckart Förster
    Institute of Anatomy, University of Freiburg, Albertstr.17, D-79104 Freiburg,Germany
  • Hans H. Bock
    Department of Molecular Genetics, UT Southwestern, 5323 Harry Hines Blvd,Dallas, TX 75390-9046, USA
  • Michael A. Hack
    Max-Planck-Institute of Neurobiology, Neuronal Specification, Am Klopferspitz 18a, D-82152 Martinsried, Germany
  • Pierre Leprince
    University of Liège, Center for Cellular and Molecular Neurobiology, 17 Place Delcour, B-4020 Liège, Belgium
  • Juan M. Luque
    Instituto de Neurociencias UMH/CSIC, Campus de San Juan s/n, E-03550 San Juan de Alicante, Spain
  • Joachim Herz
    Department of Molecular Genetics, UT Southwestern, 5323 Harry Hines Blvd,Dallas, TX 75390-9046, USA
  • Michael Frotscher
    Institute of Anatomy, University of Freiburg, Albertstr.17, D-79104 Freiburg,Germany
  • Magdalena Götz
    Max-Planck-Institute of Neurobiology, Neuronal Specification, Am Klopferspitz 18a, D-82152 Martinsried, Germany

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公開日
2003-10-01
権利情報
  • http://www.biologists.com/user-licence-1-1
DOI
  • 10.1242/dev.00654
公開者
The Company of Biologists

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説明

<jats:p>Radial glial cells are characterized, besides their astroglial properties,by long radial processes extending from the ventricular zone to the pial surface, a crucial feature for the radial migration of neurons. The molecular signals that regulate this characteristic morphology, however, are largely unknown. We show an important role of the secreted molecule reelin for the establishment of radial glia processes. We describe a significant reduction in ventricular zone cells with long radial processes in the absence of reelin in the cortex of reeler mutant mice. These defects were correlated to a decrease in the content of brain lipid-binding protein (Blbp) and were detected exclusively in the cerebral cortex, but not in the basal ganglia of reeler mice. Conversely, reelin addition in vitro increased the Blbp content and process extension of radial glia from the cortex, but not the basal ganglia. Isolation of radial glia by fluorescent-activated cell sorting showed that these effects are due to direct signaling of reelin to radial glial cells. We could further demonstrate that this signaling requires Dab1, as the increase in Blbp upon reelin addition failed to occur in Dab1-/-mice. Taken together, these results unravel a novel role of reelin signaling to radial glial cells that is crucial for the regulation of their Blbp content and characteristic morphology in a region-specific manner.</jats:p>

収録刊行物

  • Development

    Development 130 (19), 4597-4609, 2003-10-01

    The Company of Biologists

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