Estrogen Determines Sex Differences in Airway Responsiveness after Allergen Exposure

DOI PDF 被引用文献1件
  • Shigeki Matsubara
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado
  • Christina H. Swasey
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado
  • Joan E. Loader
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado
  • Azzeddine Dakhama
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado
  • Anthony Joetham
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado
  • Hiroshi Ohnishi
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado
  • Annette Balhorn
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado
  • Nobuaki Miyahara
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado
  • Katsuyuki Takeda
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado
  • Erwin W. Gelfand
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado

書誌事項

公開日
2008-05-01
権利情報
  • https://academic.oup.com/pages/standard-publication-reuse-rights
DOI
  • 10.1165/rcmb.2007-0298oc
公開者
Oxford University Press (OUP)

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<jats:title>Abstract</jats:title> <jats:p>The female hormone estrogen is an important factor in the regulation of airway function and inflammation, and sex differences in the prevalence of asthma are well described. Using an animal model, we determined how sex differences may underlie the development of altered airway function in response to allergen exposure. We compared sex differences in the development of airway hyperresponsiveness (AHR) after allergen exposure exclusively via the airways. Ovalbumin (OVA) was administered by nebulization on 10 consecutive days in BALB/c mice. After methacholine challenge, significant AHR developed in male mice but not in female mice. Ovariectomized female mice showed significant AHR after 10-day OVA inhalation. ICI182,780, an estrogen antagonist, similarly enhanced airway responsiveness even when administered 1 hour before assay. In contrast, 17β-estradiol dose-dependently suppressed AHR in male mice. In all cases, airway responsiveness was inhibited by the administration of a neurokinin 1 receptor antagonist. These results demonstrate that sex differences in 10-day OVA-induced AHR are due to endogenous estrogen, which negatively regulates airway responsiveness in female mice. Cumulatively, the results suggest that endogenous estrogen may regulate the neurokinin 1–dependent prejunctional activation of airway smooth muscle in allergen-exposed mice.</jats:p>

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