Pulmonary infiltrates and fever induced by isoniazid

E R Salomaa, E-L Ruokonen, K Tevola, E Tala

doi:10.1136/pgmj.66.778.647

Pulmonary infiltrates and fever induced by isoniazid

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E R Salomaa

Department of Diseases of the Chest, University Central Hospital of Turku , SF-21540, Preitilä, Finland
E-L Ruokonen

Department of Diseases of the Chest, University Central Hospital of Turku , SF-21540, Preitilä, Finland
K Tevola

Department of Diseases of the Chest, University Central Hospital of Turku , SF-21540, Preitilä, Finland
E Tala

Department of Diseases of the Chest, University Central Hospital of Turku , SF-21540, Preitilä, Finland

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<jats:title>Summary</jats:title> <jats:p>An 88 year old woman with bacteriologically confirmed pulmonary tuberculosis was first treated with isoniazid, rifampicin and pyrazinamide. Two weeks later she developed pulmonary infiltrates with fever. A drug-induced reaction was suspected but the reaction recurred three times until isoniazid was identified as the cause. The reaction became worse each time, finally being nearly fatal.</jats:p>