Active information maintenance in working memory by a sensory cortex

  • Xiaoxing Zhang
    State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Shanghai Center for Brain Science and Brain-Inspired Technology, Chinese Academy of Sciences, Shanghai, China
  • Wenjun Yan
    State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Shanghai Center for Brain Science and Brain-Inspired Technology, Chinese Academy of Sciences, Shanghai, China
  • Wenliang Wang
    State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Shanghai Center for Brain Science and Brain-Inspired Technology, Chinese Academy of Sciences, Shanghai, China
  • Hongmei Fan
    State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Shanghai Center for Brain Science and Brain-Inspired Technology, Chinese Academy of Sciences, Shanghai, China
  • Ruiqing Hou
    State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Shanghai Center for Brain Science and Brain-Inspired Technology, Chinese Academy of Sciences, Shanghai, China
  • Yulei Chen
    State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Shanghai Center for Brain Science and Brain-Inspired Technology, Chinese Academy of Sciences, Shanghai, China
  • Zhaoqin Chen
    State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Shanghai Center for Brain Science and Brain-Inspired Technology, Chinese Academy of Sciences, Shanghai, China
  • Chaofan Ge
    State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Shanghai Center for Brain Science and Brain-Inspired Technology, Chinese Academy of Sciences, Shanghai, China
  • Shumin Duan
    Key Laboratory of Medical Neurobiology of Ministry of Health of China, Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou, China
  • Albert Compte
    Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
  • Chengyu T Li
    State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Shanghai Center for Brain Science and Brain-Inspired Technology, Chinese Academy of Sciences, Shanghai, China

説明

<jats:p>Working memory is a critical brain function for maintaining and manipulating information over delay periods of seconds. It is debated whether delay-period neural activity in sensory regions is important for the active maintenance of information during the delay period. Here, we tackle this question by examining the anterior piriform cortex (APC), an olfactory sensory cortex, in head-fixed mice performing several olfactory working memory tasks. Active information maintenance is necessary in these tasks, especially in a dual-task paradigm in which mice are required to perform another distracting task while actively maintaining information during the delay period. Optogenetic suppression of neuronal activity in APC during the delay period impaired performance in all the tasks. Furthermore, electrophysiological recordings revealed that APC neuronal populations encoded odor information in the delay period even with an intervening distracting task. Thus, delay activity in APC is important for active information maintenance in olfactory working memory.</jats:p>

収録刊行物

  • eLife

    eLife 8 2019-06-24

    eLife Sciences Publications, Ltd

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