Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape
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- Chao Lu
- Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA.
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- Siddhant U. Jain
- Epigenetics Theme, Wisconsin Institute for Discovery, University of Wisconsin, Madison, WI 53715, USA.
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- Dominik Hoelper
- Epigenetics Theme, Wisconsin Institute for Discovery, University of Wisconsin, Madison, WI 53715, USA.
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- Denise Bechet
- Department of Human Genetics, McGill University, Montreal, Quebec H3Z 2Z3, Canada.
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- Rosalynn C. Molden
- Epigenetics Program and Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
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- Leili Ran
- Human Oncology and Pathogenesis Program and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
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- Devan Murphy
- Human Oncology and Pathogenesis Program and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
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- Sriram Venneti
- Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
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- Meera Hameed
- Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
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- Bruce R. Pawel
- Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
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- Jay S. Wunder
- University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
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- Brendan C. Dickson
- Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
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- Stefan M. Lundgren
- Epigenetics Theme, Wisconsin Institute for Discovery, University of Wisconsin, Madison, WI 53715, USA.
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- Krupa S. Jani
- Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
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- Nicolas De Jay
- Department of Human Genetics, McGill University, Montreal, Quebec H3Z 2Z3, Canada.
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- Simon Papillon-Cavanagh
- Department of Human Genetics, McGill University, Montreal, Quebec H3Z 2Z3, Canada.
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- Irene L. Andrulis
- Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
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- Sarah L. Sawyer
- Department of Medical Genetics and Children’s Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Ontario K1H 8L1, Canada.
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- David Grynspan
- Department of Medical Genetics and Children’s Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Ontario K1H 8L1, Canada.
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- Robert E. Turcotte
- Division of Orthopaedic Surgery, Montreal General Hospital, McGill University Health Centre, Montreal, Quebec H3G 1A4, Canada.
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- Javad Nadaf
- Department of Human Genetics, McGill University, Montreal, Quebec H3Z 2Z3, Canada.
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- Somayyeh Fahiminiyah
- Department of Human Genetics, McGill University, Montreal, Quebec H3Z 2Z3, Canada.
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- Tom W. Muir
- Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
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- Jacek Majewski
- Department of Human Genetics, McGill University, Montreal, Quebec H3Z 2Z3, Canada.
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- Craig B. Thompson
- Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
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- Ping Chi
- Human Oncology and Pathogenesis Program and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
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- Benjamin A. Garcia
- Epigenetics Program and Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
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- C. David Allis
- Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA.
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- Nada Jabado
- Department of Human Genetics, McGill University, Montreal, Quebec H3Z 2Z3, Canada.
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- Peter W. Lewis
- Epigenetics Theme, Wisconsin Institute for Discovery, University of Wisconsin, Madison, WI 53715, USA.
説明
<jats:title>An oncohistone deranges inhibitory chromatin</jats:title> <jats:p> Missense mutations (that change one amino acid for another) in histone H3 can produce a so-called oncohistone and are found in a number of pediatric cancers. For example, the lysine-36–to-methionine (K36M) mutation is seen in almost all chondroblastomas. Lu <jats:italic>et al.</jats:italic> show that K36M mutant histones are oncogenic, and they inhibit the normal methylation of this same residue in wild-type H3 histones. The mutant histones also interfere with the normal development of bone-related cells and the deposition of inhibitory chromatin marks. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6287" page="844" related-article-type="in-this-issue" vol="352" xlink:href="10.1126/science.aac7272">844</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 352 (6287), 844-849, 2016-05-13
American Association for the Advancement of Science (AAAS)
