Alternative splicing produces transcripts encoding two forms of the alpha subunit of GTP-binding protein Go.

M Strathmann, T M Wilkie, M I Simon

doi:10.1073/pnas.87.17.6477

Alternative splicing produces transcripts encoding two forms of the alpha subunit of GTP-binding protein Go.

DOI Web Site 被引用文献1件

M Strathmann

Division of Biology, California Institute of Technology, Pasadena 91125.
T M Wilkie

Division of Biology, California Institute of Technology, Pasadena 91125.
M I Simon

Division of Biology, California Institute of Technology, Pasadena 91125.

抄録

<jats:p>The alpha subunit of the guanine nucleotide-binding protein Go ("o" for other) is believed to mediate signal transduction between a variety of receptors and effectors. cDNA clones encoding two forms of Go alpha subunit were isolated from a mouse brain library. These two forms, which we call GoA alpha and GoB alpha, appear to be the products of alternative splicing. GoA alpha differs from GoB alpha over the C-terminal third of the deduced protein sequence. Both forms are predicted to be substrates for ADP-ribosylation by pertussis toxin. GoA alpha transcripts are present in a variety of tissues but are most abundant in brain. The GoB alpha transcript is expressed at highest levels in brain and testis. It is possible that GoA alpha and GoB alpha have different functions.</jats:p>

収録刊行物

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences 87 (17), 6477-6481, 1990-09

Proceedings of the National Academy of Sciences