Riboswitches in Eubacteria Sense the Second Messenger Cyclic Di-GMP

DOI Web Site 8 Citations
  • N. Sudarsan
    Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA.
  • E. R. Lee
    Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA.
  • Z. Weinberg
    Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA.
  • R. H. Moy
    Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA.
  • J. N. Kim
    Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA.
  • K. H. Link
    Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA.
  • R. R. Breaker
    Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA.

Description

<jats:p>Cyclic di-guanosine monophosphate (di-GMP) is a circular RNA dinucleotide that functions as a second messenger in diverse species of bacteria to trigger wide-ranging physiological changes, including cell differentiation, conversion between motile and biofilm lifestyles, and virulence gene expression. However, the mechanisms by which cyclic di-GMP regulates gene expression have remained a mystery. We found that cyclic di-GMP in many bacterial species is sensed by a riboswitch class in messenger RNA that controls the expression of genes involved in numerous fundamental cellular processes. A variety of cyclic di-GMP regulons are revealed, including some riboswitches associated with virulence gene expression, pilus formation, and flagellum biosynthesis. In addition, sequences matching the consensus for cyclic di-GMP riboswitches are present in the genome of a bacteriophage.</jats:p>

Journal

  • Science

    Science 321 (5887), 411-413, 2008-07-18

    American Association for the Advancement of Science (AAAS)

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