Comparative Analysis of Extended-Spectrum-β-Lactamase CTX-M-65-Producing Salmonella enterica Serovar Infantis Isolates from Humans, Food Animals, and Retail Chickens in the United States
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- Heather Tate
- Center for Veterinary Medicine, U.S. Food and Drug Administration, Silver Spring, Maryland, USA
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- Jason P. Folster
- National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
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- Chih-Hao Hsu
- Center for Veterinary Medicine, U.S. Food and Drug Administration, Silver Spring, Maryland, USA
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- Jessica Chen
- National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
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- Maria Hoffmann
- Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Silver Spring, Maryland, USA
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- Cong Li
- Center for Veterinary Medicine, U.S. Food and Drug Administration, Silver Spring, Maryland, USA
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- Cesar Morales
- Food Safety Inspection Service, U.S. Department of Agriculture, Washington, DC, USA
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- Gregory H. Tyson
- Center for Veterinary Medicine, U.S. Food and Drug Administration, Silver Spring, Maryland, USA
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- Sampa Mukherjee
- Center for Veterinary Medicine, U.S. Food and Drug Administration, Silver Spring, Maryland, USA
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- Allison C. Brown
- National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
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- Alice Green
- Food Safety Inspection Service, U.S. Department of Agriculture, Washington, DC, USA
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- Wanda Wilson
- Food Safety Inspection Service, U.S. Department of Agriculture, Washington, DC, USA
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- Uday Dessai
- Food Safety Inspection Service, U.S. Department of Agriculture, Washington, DC, USA
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- Jason Abbott
- Center for Veterinary Medicine, U.S. Food and Drug Administration, Silver Spring, Maryland, USA
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- Lavin Joseph
- National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
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- Jovita Haro
- Food Safety Inspection Service, U.S. Department of Agriculture, Washington, DC, USA
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- Sherry Ayers
- Center for Veterinary Medicine, U.S. Food and Drug Administration, Silver Spring, Maryland, USA
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- Patrick F. McDermott
- Center for Veterinary Medicine, U.S. Food and Drug Administration, Silver Spring, Maryland, USA
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- Shaohua Zhao
- Center for Veterinary Medicine, U.S. Food and Drug Administration, Silver Spring, Maryland, USA
Abstract
<jats:title>ABSTRACT</jats:title> <jats:p> We sequenced the genomes of 10 <jats:named-content content-type="genus-species">Salmonella enterica</jats:named-content> serovar Infantis isolates containing <jats:italic>bla</jats:italic> <jats:sub>CTX-M-65</jats:sub> obtained from chicken, cattle, and human sources collected between 2012 and 2015 in the United States through routine National Antimicrobial Resistance Monitoring System (NARMS) surveillance and product sampling programs. We also completely assembled the plasmids from four of the isolates. All isolates had a D87Y mutation in the <jats:italic>gyrA</jats:italic> gene and harbored between 7 and 10 resistance genes [ <jats:italic>aph(4)-Ia</jats:italic> , <jats:italic>aac(3)-IVa</jats:italic> , <jats:italic>aph(3</jats:italic> ′ <jats:italic>)-Ic</jats:italic> , <jats:italic>bla</jats:italic> <jats:sub>CTX-M-65</jats:sub> , <jats:italic>fosA3</jats:italic> , <jats:italic>floR</jats:italic> , <jats:italic>dfrA14</jats:italic> , <jats:italic>sul1</jats:italic> , <jats:italic>tetA</jats:italic> , <jats:italic>aadA1</jats:italic> ] located in two distinct sites of a megaplasmid (∼316 to 323 kb) similar to that described in a <jats:italic>bla</jats:italic> <jats:sub>CTX-M-65</jats:sub> -positive <jats:italic>S</jats:italic> . Infantis isolate from a patient in Italy. High-quality single nucleotide polymorphism (hqSNP) analysis revealed that all U.S. isolates were closely related, separated by only 1 to 38 pairwise high-quality SNPs, indicating a high likelihood that strains from humans, chickens, and cattle recently evolved from a common ancestor. The U.S. isolates were genetically similar to the <jats:italic>bla</jats:italic> <jats:sub>CTX-M-65</jats:sub> -positive <jats:italic>S</jats:italic> . Infantis isolate from Italy, with a separation of 34 to 47 SNPs. This is the first report of the <jats:italic>bla</jats:italic> <jats:sub>CTX-M-65</jats:sub> gene and the pESI (plasmid for emerging <jats:italic>S</jats:italic> . Infantis)-like megaplasmid from <jats:italic>S</jats:italic> . Infantis in the United States, and it illustrates the importance of applying a global One Health human and animal perspective to combat antimicrobial resistance. </jats:p>
Journal
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- Antimicrobial Agents and Chemotherapy
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Antimicrobial Agents and Chemotherapy 61 (7), 2017-07
American Society for Microbiology
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Details 詳細情報について
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- CRID
- 1362262944872359296
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- ISSN
- 10986596
- 00664804
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- Data Source
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- Crossref