Current Approaches to Bone Tissue Engineering: The Interface between Biology and Engineering
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- Jiao Jiao Li
- Biomaterials and Tissue Engineering Research Unit School of Aerospace, Mechanical and Mechatronic Engineering University of Sydney Sydney NSW 2006 Australia
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- Mohamed Ebied
- Radcliffe Institute for Advanced Study Harvard University Cambridge MA 02138 USA
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- Jen Xu
- Radcliffe Institute for Advanced Study Harvard University Cambridge MA 02138 USA
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- Hala Zreiqat
- Biomaterials and Tissue Engineering Research Unit School of Aerospace, Mechanical and Mechatronic Engineering University of Sydney Sydney NSW 2006 Australia
説明
<jats:title>Abstract</jats:title><jats:p>The successful regeneration of bone tissue to replace areas of bone loss in large defects or at load‐bearing sites remains a significant clinical challenge. Over the past few decades, major progress is achieved in the field of bone tissue engineering to provide alternative therapies, particularly through approaches that are at the interface of biology and engineering. To satisfy the diverse regenerative requirements of bone tissue, the field moves toward highly integrated approaches incorporating the knowledge and techniques from multiple disciplines, and typically involves the use of biomaterials as an essential element for supporting or inducing bone regeneration. This review summarizes the types of approaches currently used in bone tissue engineering, beginning with those primarily based on biology or engineering, and moving into integrated approaches in the areas of biomaterial developments, biomimetic design, and scalable methods for treating large or load‐bearing bone defects, while highlighting potential areas for collaboration and providing an outlook on future developments.</jats:p>
収録刊行物
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- Advanced Healthcare Materials
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Advanced Healthcare Materials 7 (6), 1701061-, 2017-12-27
Wiley
