The relationship among acute-phase responce proteins, cytokines, and hormones in various gastrointestinal cancer types patients with cachectic

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  • O Kemik
    Department of General Surgery, Yuzuncu Yı;l University Medical Faculty, Van, Turkey
  • AS Kemik
    Department of Biochemistry, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
  • H Begenik
    Department of Internal Medicine, Yuzuncu Yı;l University Medical Faculty, Van, Turkey
  • FM Erdur
    Department of Internal Medicine, Yuzuncu Yı;l University Medical Faculty, Van, Turkey
  • H Emre
    Department of Internal Medicine, Yuzuncu Yı;l University Medical Faculty, Van, Turkey
  • A Sumer
    Department of General Surgery, Yuzuncu Yı;l University Medical Faculty, Van, Turkey
  • S Purisa
    Department of Biostatistics, Istanbul Medical Faculty, University of Istanbul, Istanbul, Turkey
  • S Tuzun
    Department of General Surgery, Haseki Education and Research Hospital, Istanbul, Turkey
  • C Kotan
    Department of General Surgery, Yuzuncu Yı;l University Medical Faculty, Van, Turkey

Description

<jats:p> Background: Acute-phase response proteins (APRPs), cytokines, and hormones have been claimed to be an independent, important factor of cancers. We suggest that in gastrointestinal system cancers, changes in APRP, cytokines, and hormones are associated.Methods: C-reactive protein (CRP), albumin, interleukin 1α (IL-1α), IL-1β, IL-6, IL-8, IL-10, tumor necrosis factor α (TNF-α), midkine, vascular endothelial growth factor-A(VEGF-A), VEGF-C, VEGF receptor 1 (VEGFR1), leptin, adiponectin, and ghrelin serum levels are studied in 148 gastrointestinal system cancer types and 40 healthy controls.Results: We found statistically significant differences and correlations between groups. We found significantly higher serum CRP, IL-1α, IL-1β, IL-6, IL-8, IL-10, TNF-α, VEGF-A, VEGF-C, VEGFR1, and leptin concentrations in patients with esophageal, gastric, pancreas, colon, and rectum cancers than controls ( p < 0.001, p < 0.0001). But, we found lower levels of the serum albumin, midkine, adiponectin, and ghrelin in patients with esophageal, gastric, pancreas, colon, and rectum cancers compared to control subjects ( p < 0.05, p < 0.001).Conclusions: Cachexia in gastrointestinal system cancer types is associated with changes in APRP, cytokines, and hormone concentrations. This may be reflected between the outcomes in malignancies and the biomarkers. </jats:p>

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