Hundred joules plasma focus device as a potential pulsed source for <i>in vitro</i> cancer cell irradiation
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- J. Jain
- Universidad de Talca 1 , 2 Norte 685, Casilla 721, Talca, Chile
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- J. Moreno
- Comisión Chilena de Energía Nuclear 2 , Casilla 188-D, Santiago, Chile
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- R. Andaur
- Departamento de Oncología Básico-clínica, Facultad de Medicina, Universidad de Chile 4 , Independencia 1027, Independencia, Santiago, Chile
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- R. Armisen
- Centro de Investigación y Tratamiento del Cáncer, Facultad de Medicina, Universidad de Chile 5 , Independencia 1027, Independencia, Santiago, Chile
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- D. Morales
- Comisión Chilena de Energía Nuclear 2 , Casilla 188-D, Santiago, Chile
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- K. Marcelain
- Departamento de Oncología Básico-clínica, Facultad de Medicina, Universidad de Chile 4 , Independencia 1027, Independencia, Santiago, Chile
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- G. Avaria
- Comisión Chilena de Energía Nuclear 2 , Casilla 188-D, Santiago, Chile
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- B. Bora
- Comisión Chilena de Energía Nuclear 2 , Casilla 188-D, Santiago, Chile
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- S. Davis
- Comisión Chilena de Energía Nuclear 2 , Casilla 188-D, Santiago, Chile
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- C. Pavez
- Comisión Chilena de Energía Nuclear 2 , Casilla 188-D, Santiago, Chile
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- L. Soto
- Comisión Chilena de Energía Nuclear 2 , Casilla 188-D, Santiago, Chile
抄録
<jats:p>Plasma focus devices may arise as useful source to perform experiments aimed to study the effects of pulsed radiation on human cells in vitro. In the present work, a table top hundred joules plasma focus device, namely “PF-400J”, was adapted to irradiate colorectal cancer cell line, DLD-1. For pulsed x-rays, the doses (energy absorbed per unit mass, measured in Gy) were measured using thermoluminescence detectors (TLD-100 dosimeters). The neutron fluence and the average energy were used to estimate the pulsed neutron doses. Fifty pulses of x-rays (0.12 Gy) and fifty pulses of neutrons (3.5 μGy) were used to irradiate the cancer cells. Irradiation-induced DNA damage and cell death were assessed at different time points after irradiation. Cell death was observed using pulsed neutron irradiation, at ultralow doses. Our results indicate that the PF-400J can be used for in vitro assessment of the effect of pulsed radiation in cancer cell research.</jats:p>
収録刊行物
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- AIP Advances
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AIP Advances 7 (8), 2017-08-01
AIP Publishing