Cataracts among Chernobyl Clean-up Workers: Implications Regarding Permissible Eye Exposures
書誌事項
- 公開日
- 2007-02
- DOI
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- 10.1667/rr0298.1
- 公開者
- Radiation Research Society
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説明
The eyes of a prospective cohort of 8,607 Chernobyl clean-up workers (liquidators) were assessed for cataract at 12 and 14 years after exposure. The prevalence of strictly age-related cataracts was low, as expected (only 3.9% had nuclear cataracts at either examination), since 90% of the cohort was younger than 55 years of age at first examination. However, posterior subcapsular or cortical cataracts characteristic of radiation exposure were present in 25% of the subjects. The data for Stage 1 cataracts, and specifically for posterior subcapsular cataracts, revealed a significant dose response. When various cataract end points were analyzed for dose thresholds, the confidence intervals all excluded values greater than 700 mGy. Linear-quadratic dose-response models yielded mostly linear associations, with weak evidence of upward curvature. The findings do not support the ICRP 60 risk guideline assumption of a 5-Gy threshold for "detectable opacities" from protracted exposures but rather point to a dose-effect threshold of under 1 Gy. Thus, given that cataract is the dose-limiting ocular pathology in current eye risk guidelines, revision of the allowable exposure of the human visual system to ionizing radiation should be considered.
収録刊行物
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- Radiation Research
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Radiation Research 167 (2), 233-243, 2007-02
Radiation Research Society
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詳細情報 詳細情報について
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- CRID
- 1362262944971230464
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- DOI
- 10.1667/rr0298.1
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- ISSN
- 19385404
- 00337587
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- PubMed
- 17390731
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- データソース種別
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- Crossref
- OpenAIRE
