A Concise and Efficient Total Synthesis of Militarinone D

Uttam Dash, Sandip Sengupta, Taebo Sim

doi:10.1002/ejoc.201500380

A Concise and Efficient Total Synthesis of Militarinone D

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書誌事項

公開日: 2015-05-15

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http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1002/ejoc.201500380

公開者: Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>A highly stereoselective, concise (14 steps longest linear sequence and 20 steps overall), and efficient (15 % overall yield) synthesis of militarinone D has been accomplished. The key reactions utilized in the sequence are enzymatic desymmetrization, <jats:italic>cis</jats:italic>/<jats:italic>trans</jats:italic> isomerization, Horner–Wadsworth–Emmons olefination, and addition of an organolithium species to a highly conjugated chiral aldehyde. The simplicity of the strategy may enable its utilization in the large‐scale production of this target. Moreover, the strategy utilized to design the route should be applicable to the preparation of analogs that bear a variety of substituted pyridinone core structures.</jats:p>