Brain metabolites as <sup>1</sup>H NMR markers of neuronal and glial disorders

S. S. Gill, R. K. Small, D. G. T. Thomas, P. Patel, R. Porteous, N. Van Bruggen, D. G. Gadian, R. A. Kauppinen, S. R. Williams

doi:10.1002/nbm.1940020505

Brain metabolites as <sup>1</sup>H NMR markers of neuronal and glial disorders

DOI Web Site Web Site 被引用文献3件

書誌事項

公開日: 1989-12

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http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1002/nbm.1940020505

公開者: Wiley

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<jats:title>Abstract</jats:title><jats:p><jats:sup>1</jats:sup>H NMR spectroscopy of human brain <jats:italic>in vivo</jats:italic> can be used to detect a number of cerebral metabolites including <jats:italic>N</jats:italic>‐acetylaspartate, creatine + phosphocreatine and choline‐containing compounds. We have used <jats:sup>1</jats:sup>H NMR spectroscopy to analyse these signals in (i) biopsy material from both normal human brain and astrocytomas, and (ii) primary astrocyte cultures. On the basis of this analysis, we conclude that <jats:italic>in vivo</jats:italic> <jats:sup>1</jats:sup>H NMR spectroscopy could play an important clinical role in the non‐invasive assessment of neuronal degeneration and proliferation of non‐neuronal cells.</jats:p>