Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

DOI Web Site Web Site 11 Citations
  • Divij Mathew
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Josephine R. Giles
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Amy E. Baxter
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Derek A. Oldridge
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Allison R. Greenplate
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Jennifer E. Wu
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Cécile Alanio
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Leticia Kuri-Cervantes
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • M. Betina Pampena
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Kurt D’Andrea
    Division of Translational Medicine and Human Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Sasikanth Manne
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Zeyu Chen
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Yinghui Jane Huang
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • John P. Reilly
    Division of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Ariel R. Weisman
    Division of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Caroline A. G. Ittner
    Division of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Oliva Kuthuru
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Jeanette Dougherty
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Kito Nzingha
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Nicholas Han
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Justin Kim
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Ajinkya Pattekar
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Eileen C. Goodwin
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Elizabeth M. Anderson
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Madison E. Weirick
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Sigrid Gouma
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Claudia P. Arevalo
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Marcus J. Bolton
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Fang Chen
    Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Simon F. Lacey
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Holly Ramage
    Department of Microbiology, Thomas Jefferson University, Philadelphia, PA, USA.
  • Sara Cherry
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Scott E. Hensley
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Sokratis A. Apostolidis
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Alexander C. Huang
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Laura A. Vella
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Michael R. Betts
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Nuala J. Meyer
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • E. John Wherry
    Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Zahidul Alam
  • Mary M. Addison
  • Katelyn T. Byrne
  • Aditi Chandra
  • Hélène C. Descamps
  • Yaroslav Kaminskiy
  • Jacob T. Hamilton
  • Julia Han Noll
  • Dalia K. Omran
  • Eric Perkey
  • Elizabeth M. Prager
  • Dana Pueschl
  • Jennifer B. Shah
  • Jake S. Shilan
  • Ashley N. Vanderbeck

Abstract

<jats:title>Immune profiling of COVID-19 patients</jats:title> <jats:p> Coronavirus disease 2019 (COVID-19) has affected millions of people globally, yet how the human immune system responds to and influences COVID-19 severity remains unclear. Mathew <jats:italic>et al.</jats:italic> present a comprehensive atlas of immune modulation associated with COVID-19. They performed high-dimensional flow cytometry of hospitalized COVID-19 patients and found three prominent and distinct immunotypes that are related to disease severity and clinical parameters. Arunachalam <jats:italic>et al.</jats:italic> report a systems biology approach to assess the immune system of COVID-19 patients with mild-to-severe disease. These studies provide a compendium of immune cell information and roadmaps for potential therapeutic interventions. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abc8511">eabc8511</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6508" page="1210" related-article-type="in-this-issue" vol="369" xlink:href="10.1126/science.abc6261">1210</jats:related-article> </jats:p>

Journal

  • Science

    Science 369 (6508), eabc8511-, 2020-09-04

    American Association for the Advancement of Science (AAAS)

Citations (11)*help

See more

Report a problem

Back to top